Introduction: A covered stent is one whose length and circumference is enclosed with a membrane or fabric like material. Current covered stents have been used in the treatment of failed saphenous vein grafts in coronary bypass and coronary artery perforations. Covered stents have also been proposed in treating brain aneurysm. However, none of these applications showed satisfactory results. The deficiencies of the covered stents are 1) Large wall thickness 2) Rigidity 3) Non-biodegradable polymer with poor endothelialization. Materials and methods: Aligned poly(L-lactide-co-epsilon-caprolactone) [P(LLA-CL)] nanofiber was lon-gitudinally deposited on to a bare metal stent (BMS) by a patent pending electrospinning technique. The NCS were deployed following the instruction to evaluate the expandability. Biocompatibility of the nanofiber was characterized by cell culture, degradation and drug eluting study. Results: The cell viability of Porcine smooth muscle cells (PSMC) on the nanofiber was initially low but caught up after . SEM images showed 100% of cell confluence on the nanofiber after . Significant amount of ECM protein was detected on P(LLA-CL) nanofiber ( at day 70). Complete degradation of P(LLA-CL) is expected within . Paclitaxel released from drug loaded nanofiber was shown to inhibit PSMC growth but kill Hela cells. NCS was successfully fabricated and deployed without tearing the nanofiber. Conclusions: NCS was successfully fabricated. P(LLA-CL) was chosen for the “cover” with proved superiorities on biocompatibility, cell viability, degradability and drug loading capacity. Future work will be animal study to prove that NCS can reduce in-stent restenosis and promote endothelialization.
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Design Of Medical Devices Conference Abstracts
Nanofiber Covered Stent (NCS) for Vascular Diseases
Yixiang Dong,
Yixiang Dong
Division of Bioengineering,
National University of Singapore
, Singapore
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Teo Wee Eong,
Teo Wee Eong
Division of Bioengineering,
National University of Singapore
, Singapore
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Susan Liao,
Susan Liao
Division of Bioengineering,
National University of Singapore
, Singapore
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Casey Chan,
Casey Chan
Division of Bioengineering,
National University of Singapore
, Singapore
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S. Ramakrishna
S. Ramakrishna
Division of Bioengineering,
National University of Singapore
, Singapore
Search for other works by this author on:
Yixiang Dong
Division of Bioengineering,
National University of Singapore
, Singapore
Teo Wee Eong
Division of Bioengineering,
National University of Singapore
, Singapore
Susan Liao
Division of Bioengineering,
National University of Singapore
, Singapore
Casey Chan
Division of Bioengineering,
National University of Singapore
, Singapore
S. Ramakrishna
Division of Bioengineering,
National University of Singapore
, SingaporeJ. Med. Devices. Jun 2008, 2(2): 027512 (1 pages)
Published Online: June 11, 2008
Article history
Published:
June 11, 2008
Citation
Dong, Y., Eong, T. W., Liao, S., Chan, C., and Ramakrishna, S. (June 11, 2008). "Nanofiber Covered Stent (NCS) for Vascular Diseases." ASME. J. Med. Devices. June 2008; 2(2): 027512. https://doi.org/10.1115/1.2936115
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