The last-stage bladed disk of a steam turbine is analyzed with respect to both flutter susceptibility and limitation of forced response. Due to the lack of variable stator vanes, unfavorable flow conditions may occur, which can lead to flow separation in some circumstances. Consequently, there is the risk of flutter in principle, particularly at nominal speed under part load conditions. For this reason, intentional mistuning is employed by the manufacturer with the objective to prevent any self-excited vibrations. A first step in this direction is done by choosing alternate mistuning, which keeps the manufactural efforts in limits since only two different blade designs are allowed. In this sense, two different series of blades have been made. However, it is well known that small deviations from the design intention are unavoidable due to the manufacturing procedure, which could be proved by bonk tests carried out earlier. The influence of these additional but unwanted deviations is considered in numerical simulations. Moreover, the strong dependence of blade frequencies on the speed is taken into account since centrifugal stiffening effects significantly attenuate the blade-to-blade frequency difference in this particular case. Focusing on the first flap mode, it could be shown that a mitigation of flutter susceptibility is achieved by prescribing alternate mistuning, which indeed evokes an increase of originally small aerodynamic damping ratios. Nevertheless, the occurrence of negative damping ratios could not be completely precluded at part load conditions. That is why optimization studies are conducted based on genetic algorithms with the objective function of maximizing the lowest aerodynamic damping ratios. Again, only two different blade designs are admitted. Finally, mistuning patterns could be identified causing a tremendous increase of aerodynamic damping ratios. The robustness of the solutions found could be proved by superimposing additional random mistuning.