https://orcid.org/0000-0002-8707-6133
Abstract
This work explores the characteristics of a two-phase system's dispersed phase flow that interacts inside the microfluidic channel at the junction. Direct visualization and μ-particle image velocimetry measurements are performed on the interaction of two immiscible fluids in different stepped flow-focusing (SFF) channels for droplet formation. The capillary instabilities produce the counter-rotating vortex flow in dispersed phase fluid at the interface, which plays a significant role in droplet formation. The vortex flow has been analyzed using various data processing techniques. The effect of flowrate and step channel dimensions on the evolution of the vortices generated during droplet thread propagation is studied. The strength of the vortex and momentum flux led to the development of more bulging shapes in the droplet thread. Also, this study exhibits transient flow characteristics during the detachment stage and contributes to understanding its influences on mass transfer at the microlevel dimensions.
References
1.
Liu
, H.
, and Zhang
, Y.
, 2011
, “Droplet Formation in Microfluidic Cross-Junctions
,” Phys. Fluids
, 23
(8
), p. 082101
.10.1063/1.36156432.
Crowe
, C. D.
, and Keating
, C. D.
, 2022
, “Microfluidic Control of Coexisting Chemical Microenvironments Within Multiphase Water-in-Fluorocarbon Droplets
,” Langmuir
, 38
(5
), pp. 1811
–1820
.10.1021/acs.langmuir.1c029293.
Yetisen
, A. K.
, Akram
, M. S.
, and Lowe
, C. R.
, 2013
, “Paper-Based Microfluidic Point-of-Care Diagnostic Devices
,” Lab Chip
, 13
(12
), pp. 2210
–2251
.10.1039/c3lc50169h4.
Hajba
, L.
, and Guttman
, A.
, 2017
, “Continuous-Flow-Based Microfluidic Systems for Therapeutic Monoclonal Antibody Production and Organ-on-a-Chip Drug Testing
,” J. Flow Chem.
, 7
(3–4
), pp. 118
–123
.10.1556/1846.2017.000145.
Mehta
, P.
, Rahman
, Z.
, ten Dijke
, P.
, and Boukany
, P. E.
, 2022
, “Microfluidics Meets 3D Cancer Cell Migration
,” Trends Cancer
, 8
(8
), pp. 683
–697
.10.1016/j.trecan.2022.03.0066.
Glawdel
, T.
, and Ren
, C. L.
, 2012
, “Droplet Formation in Microfluidic T-Junction Generators Operating in the Transitional Regime. III. Dynamic Surfactant Effects
,” Phys. Rev. E - Stat. Nonlinear, Soft Matter Phys.
, 86
(2
), p. 026308
.10.1103/PhysRevE.86.0263087.
van Loo
, S.
, Stoukatch
, S.
, Kraft
, M.
, and Gilet
, T.
, 2016
, “Droplet Formation by Squeezing in a Microfluidic Cross-Junction
,” Microfluid. Nanofluid.
, 20
(10
), pp. 1
–12
.10.1007/s10404-016-1807-18.
Doufène
, K.
, Tourné-Péteilh
, C.
, Etienne
, P.
, and Aubert-Pouëssel
, A.
, 2019
, “Microfluidic Systems for Droplet Generation in Aqueous Continuous Phases: A Focus Review
,” Langmuir
, 35
(39
), pp. 12597
–12612
.10.1021/acs.langmuir.9b021799.
Hernández-Cid
, D.
, Pérez-González
, V. H.
, Gallo-Villanueva
, R. C.
, González-Valdez
, J.
, and Mata-Gómez
, M. A.
, 2022
, “Modeling Droplet Formation in Microfluidic Flow-Focusing Devices Using the Two-Phases Level Set Method
,” Mater. Today Proc.
, 48
, pp. 30
–40
.10.1016/j.matpr.2020.09.41710.
Baroud
, C. N.
, Gallaire
, F.
, and Dangla
, R.
, 2010
, “Dynamics of Microfluidic Droplets
,” Lab Chip
, 10
(16
), pp. 2032
–2045
.10.1039/c001191f11.
Yu
, W.
, Liu
, X.
, Zhao
, Y.
, and Chen
, Y.
, 2019
, “Droplet Generation Hydrodynamics in the Microfluidic Cross-Junction With Different Junction Angles
,” Chem. Eng. Sci.
, 203
, pp. 259
–284
.10.1016/j.ces.2019.03.08212.
Soroor
, M.
, Zabetian Targhi
, M.
, and Tabatabaei
, S. A.
, 2021
, “Numerical and Experimental Investigation of a Flow Focusing Droplet-Based Microfluidic Device
,” Eur. J. Mech. B/Fluids
, 89
, pp. 289
–300
.10.1016/j.euromechflu.2021.06.01313.
Van Der Graaf
, S.
, Steegmans
, M. L. J.
, Van Der Sman
, R. G. M.
, Schroën
, C. G. P. H.
, and Boom
, R. M.
, 2005
, “Droplet Formation in a T-Shaped Microchannel Junction: A Model System for Membrane Emulsification
,” Colloids Surf., A
, 266
(1–3
), pp. 106
–116
.10.1016/j.colsurfa.2005.06.01914.
Khan
, A. H.
, Ganguli
, A.
, Edirisinghe
, M.
, and Dalvi
, S. V.
, 2023
, “Experimental and Computational Investigation of Microbubble Formation in a Single Capillary Embedded T-Junction Microfluidic Device
,” Langmuir
, 39
(51
), pp. 18971
–18982
.10.1021/acs.langmuir.3c0298215.
Roumpea
, E.
, Kovalchuk
, N. M.
, Chinaud
, M.
, Nowak
, E.
, Simmons
, M. J. H.
, and Angeli
, P.
, 2019
, “Experimental Studies on Droplet Formation in a Flow-Focusing Microchannel in the Presence of Surfactants
,” Chem. Eng. Sci.
, 195
, pp. 507
–518
.10.1016/j.ces.2018.09.04916.
Van Steijn
, V.
, Kleijn
, C. R.
, and Kreutzer
, M. T.
, 2009
, “Flows Around Confined Bubbles and Their Importance in Triggering Pinch-Off
,” Phys. Rev. Lett.
, 103
(21
), pp. 1
–4
.10.1103/PhysRevLett.103.21450117.
Funfschilling
, D.
, Debas
, H.
, Li
, H. Z.
, and Mason
, T. G.
, 2009
, “Flow-Field Dynamics During Droplet Formation by Dripping in Hydrodynamic-Focusing Microfluidics
,” Phys. Rev. E - Stat. Nonlinear, Soft Matter Phys.
, 80
(1
), p. 015301(R)
..10.1103/PhysRevE.80.01530118.
Gu
, M.
, Li
, J.
, Hossain
, M.
, and Xu
, C.
, 2023
, “High-Resolution Microscale Velocity Field Measurement Using Light Field Particle Image-Tracking Velocimetry
,” Phys. Fluids
, 35(11), p. 112006
.10.1063/5.017493719.
Liu
, Z.
, Li
, M.
, Pang
, Y.
, Zhang
, L.
, Ren
, Y.
, and Wang
, J.
, 2019
, “Flow Characteristics Inside Droplets Moving in a Curved Microchannel With Rectangular Section
,” Phys. Fluids
, 31
(2
), p. 022004
.10.1063/1.508037320.
Fu
, T.
, Ma
, Y.
, Funfschilling
, D.
, and Li
, H. Z.
, 2009
, “Bubble Formation and Breakup Mechanism in a Microfluidic Flow-Focusing Device
,” Chem. Eng. Sci.
, 64
(10
), pp. 2392
–2400
.10.1016/j.ces.2009.02.02221.
Paiboon
, N.
, Surassmo
, S.
, Ruktanonchai
, U. R.
, and Soottitantawat
, A.
, 2022
, “Hydrodynamic Control of Droplet Formation in Narrowing Jet and Tip Streaming Regime Using Microfluidic Flow-Focusing
,” Int. J. Multiphase Flow
, 150
, p. 104013
.10.1016/j.ijmultiphaseflow.2022.10401322.
Hettiarachchi
, S.
, Melroy
, G.
, Mudugamuwa
, A.
, Sampath
, P.
, Premachandra
, C.
, Amarasinghe
, R.
, and Dau
, V.
, 2021
, “Design and Development of a Microfluidic Droplet Generator With Vision Sensing for Lab-on-a-Chip Devices
,” Sens. Actuators, A
, 332
, p. 113047
.10.1016/j.sna.2021.11304723.
Wu
, L.
, Liu
, X.
, Zhao
, Y.
, and Chen
, Y.
, 2017
, “Role of Local Geometry on Droplet Formation in Axisymmetric Microfluidics
,” Chem. Eng. Sci.
, 163
, pp. 56
–67
.10.1016/j.ces.2017.01.02224.
Herland
, A.
, Van Der Meer
, A. D.
, FitzGerald
, E. A.
, Park
, T. E.
, Sleeboom
, J. J. F.
, and Ingber
, D. E.
, 2016
, “Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip
,” PLoS One
, 11
(3
), p. e0150360
.10.1371/journal.pone.015036025.
Xiong
, R.
, Bai
, M.
, and Chung
, J. N.
, 2007
, “Formation of Bubbles in a Simple co-Flowing Micro-Channel
,” J. Micromech. Microeng.
, 17
(5
), pp. 1002
–1011
.10.1088/0960-1317/17/5/02126.
Zhu
, Z. J.
, Niu
, J. L.
, and Li
, Y. L.
, 2014
, “Swirling-Strength Based Large Eddy Simulation of Turbulent Flow Around Single Square Cylinder at Low Reynolds Numbers
,” Appl. Math. Mech.
, 35
(8
), pp. 959
–978
.10.1007/s10483-014-1847-727.
Steiner
, O.
, 2020
, “A Dynamical Equation for the Swirling Strength
,” Astron. Astrophys.
, 639, pp. 1
–12
.10.1051/0004?6361/20203806028.
Carlier
, J.
, and Stanislas
, M.
, 2005
, “Experimental Study of Eddy Structures in a Turbulent Boundary Layer Using Particle Image Velocimetry
,” J. Fluid Mech.
, 535
, pp. 143
–188
.10.1017/S002211200500475129.
Wang
, J.
, Pan
, C.
, Choi
, K. S.
, Gao
, L.
, and Lian
, Q. X.
, 2013
, “Formation, Growth and Instability of Vortex Pairs in an Axisymmetric Stagnation Flow
,” J. Fluid Mech.
, 725
, pp. 681
–708
.10.1017/jfm.2013.20530.
Scarano
, F.
, Benocci
, C.
, and Riethmuller
, M. L.
, 1999
, “Pattern Recognition Analysis of the Turbulent Flow Past a Backward Facing Step
,” Phys. Fluids
, 11
(12
), pp. 3808
–3818
.10.1063/1.87024031.
Ma
, S.
, Sherwood
, J. M.
, Huck
, W. T. S.
, and Balabani
, S.
, 2014
, “On the Flow Topology Inside Droplets Moving in Rectangular Microchannels
,” Lab Chip
, 14
(18
), pp. 3611
–3620
.10.1039/C4LC00671B32.
Maurya
, T. C. K.
, and Dutta
, S.
, 2023
, “Pinch-Off Dynamics of Droplet Formation in Microchannel Flow
,” Chem. Eng. Sci.
, 282
, p. 119296
.10.1016/j.ces.2023.11929633.
Chen
, C.
, Jing
, Z.
, Feng
, C.
, Zou
, X.
, Qiao
, M.
, Xu
, D.
, and Wang
, S.
, 2023
, “Two-Phase Flow and Morphology of the Gas–Liquid Interface for Bubbles or Droplets in Different Microchannels
,” Phys. Fluids
, 35
, p. 091302
.10.1063/5.015747334.
Lu
, Y.
, Fu
, T.
, Zhu
, C.
, Ma
, Y.
, and Li
, H. Z.
, 2016
, “Experimental Investigation on the Breakup Dynamics for Bubble Formation in Viscous Liquids in a Flow-Focusing Device
,” Chem. Eng. Sci.
, 152
, pp. 516
–527
.10.1016/j.ces.2016.06.04835.
Mousavi
, S. M.
, Jarrahbashi
, D.
, Lee
, B. J.
, Karimi
, N.
, and Faroughi
, S. A.
, 2023
, “Impact of Hybrid Surfaces on the Droplet Breakup Dynamics in Microgravity Slug Flow: A Dynamic Contact Angle Analysis
,” Phys. Fluids
, 35
(7
), p. 072003
.10.1063/5.015911836.
Jena
, S. K.
, Bahga
, S. S.
, and Kondaraju
, S.
, 2021
, “Prediction of Droplet Sizes in a T-Junction Microchannel: Effect of Dispersed Phase Inertial Forces
,” Phys. Fluids
, 33
(3
), p. 032120
.10.1063/5.003991337.
Vagner
, S. A.
, Patlazhan
, S. A.
, Serra
, C. A.
, and Funfschilling
, D.
, 2021
, “Vortex Flow Evolution in a Growing Microdroplet During co-Flow in Coaxial Capillaries
,” Phys. Fluids
, 33
(7
), p. 072010
.10.1063/5.005735338.
Sarrazin
, F.
, Loubière
, K.
, Prat
, L.
, Gourdon
, C.
, Bonometti
, T.
, and Magnaudet
, J.
, 2006
, “Experimental and Numerical Study of Droplets Hydrodynamics in MicroChannel
,” AIChE J.
, 52
(12
), pp. 4061
–4070
.10.1002/aic.11033
