... strain best maintains native physiology while promoting extracellular matrix (ECM) turnover for both age groups. However, aged tendons display fewer strain-dependent changes, suggesting a reduced ability to adapt to altered levels of mechanical loading. This work has a significant impact on understanding...

... February 5, 2014. Editor: Victor H. Barocas. 16 10 2013 28 12 2013 09 01 2014 Tumor progression depends critically upon the interactions between the tumor cells and their microenvironment. The tumor microenvironment is heterogeneous and dynamic; it consists of extracellular matrix...

... , pp. 538 – 561 . 10.1111/j.1365-2796.2003.01297.x [4] Ingber , D. E. , 2002 , “ Mechanical Signaling and the Cellular Response to Extracellular Matrix in Angiogenesis and Cardiovascular Physiology ,” Circ. Res. , 91 , pp. 877 – 887 . 10.1161/01.RES.0000039537.73816.E5 [5] Li...

... cryopreservation, ice forms in the extracellular space resulting in freezing-induced deformation of the tissue, which can be detrimental to the extracellular matrix (ECM) microstructure. Meanwhile, cells dehydrate through an osmotically driven process as the intracellular water is transported to the extracellular...

... of extracellular matrix proteins. In particular, the mutated form of the fibrillin-1 gene disrupts collagen synthesis, as the native protein is required for the formation of collagen microfibrils. In vitro cell culture experiments have demonstrated that fibroblasts isolated from MFS patients are limited...

... microstructure extracellular matrix two-photon sclera glaucoma multiphoton According to the World Health Organization, glaucoma is estimated to affect 80 × 10 6 people by 2020 worldwide, making it the second leading cause of blindness [( 1 )]. The diagnosis and treatment strategies for primary open...

...Blayne A. Roeder; Klod Kokini; Sherry L. Voytik-Harbin The next generation of medical devices and engineered tissues will require development of scaffolds that mimic the structural and functional properties of the extracellular matrix (ECM) component of tissues. Unfortunately, little is known...

... quantified. Local collagen fiber alignment in the same valves was also quantified using small angle light scattering. A tissue-level finite element (FE) model of an AVIC embedded in the AV extracellular matrix was also used explore the relation between AV tissue- and cellular-level deformations. Results...

...Blayne A. Roeder; Klod Kokini; J. Paul Robinson; Sherry L. Voytik-Harbin The ability to create extracellular matrix (ECM) constructs that are mechanically and biochemically similar to those found in vivo and to understand how their properties affect cellular responses will drive the next generation...

... and that changes in extracellular matrix composition and matrix gene expression in the presence of RA/AA treatment may play an important role in the development of said mechanical properties. AoSMC were obtained from Clonetics Corporation (San Diego, CA). Cells were maintained in smooth muscle growth media...

...Blayne A. Roeder; Klod Kokini; Jennifer E. Sturgis; J. Paul Robinson; Sherry L. Voytik-Harbin The importance and priority of specific micro-structural and mechanical design parameters must be established to effectively engineer scaffolds (biomaterials) that mimic the extracellular matrix (ECM...