...Nathan J. Witt; Alan E. Woessner; Jacob Herrmann; Kyle P. Quinn; Edward A. Sander Skin undergoes mechanical alterations due to changes in the composition and structure of the collagenous dermis with aging. Previous studies have conflicting findings, with both increased and decreased stiffness...

...), approaches to reinforce or rebuild degenerative cartilage are of significant interest. While exogenous collagen crosslinking (CXL) treatments improve cartilage's mechanical properties and increase its resistance to enzymatic degradation, their effects on cartilage lubrication remain less clear. Here, we...

...Ning-Jiun Jan; Po-Yi Lee; Jacob Wallace; Michael Iasella; Alexandra Gogola; Bingrui Wang; Ian A. Sigal Stretch-induced collagen uncrimping underlies the nonlinear mechanical behavior of the sclera according to what is often called the process of recruitment. We recently reported experimental...

... that skin has a high Poisson's ratio, substantially decreases in volume during uniaxial tensile loading, and demonstrates collagen fiber kinematics that are not affine with local deformation. In order to better understand the mechanical basis for these properties, we constructed multiscale mechanical models...

... it. We propose a mathematical model of fibrous networks, which reproduces qualitative features of collagen gel's stress–strain response and provides insight into the key features which impact the Young's modulus of similar fibrous tissues. This model analyzes the relationship of the Young's modulus...

...Christopher E. Korenczuk; Victor H. Barocas; William J. Richardson The scar that forms after a myocardial infarction is often characterized by a highly disordered architecture but generally exhibits some degree of collagen fiber orientation, with a resulting mechanical anisotropy. When viewed...

...) and had higher collagen content (16.10 ± 3.80%) than the myocardium (SM 2 = 55.14 ± 20.49 KPa, collagen content = 10.06 ± 4.15%) in the left ventricle. The results of this study improve our understanding of the contribution of trabeculae carneae to left ventricular compliance and will be useful...

.... Currently, the model does not consider the concentric, circumferential layers of elastin, collagen, and smooth muscle, which form the medial lamellae [ 39 ]. Unlike the current study, which considers the failure of the fibers within the lamellae, a study with radial and shear loading would involve...

...) is a rapidly fatal disease in which mortality is typically due to right ventricular (RV) failure. An excellent predictor of mortality in PAH is proximal pulmonary artery stiffening, which is mediated by collagen accumulation in hypoxia-induced pulmonary hypertension (HPH) in mice. We sought to investigate...

...Mohammad F. Hadi; Victor H. Barocas While differences in collagen fiber alignment played a role in prescribing macroscale failure outcomes, the model must be expanded to consider the role of fiber-to-fiber connectivity, intrafibrillar matrix, and multiple protein networks in order to simulate...

... a multiscale mechanical model for the failure of collagenous soft tissues that incorporates spatial heterogeneity in the microstructure and links the failure of discrete collagen fibers to the material response of the tissue. The model, which is based on experimental failure data derived from different...

...Victor K. Lai; Spencer P. Lake; Christina R. Frey; Robert T. Tranquillo; Victor H. Barocas Fibrin and collagen, biopolymers occurring naturally in the body, are biomaterials commonly-used as scaffolds for tissue engineering. How collagen and fibrin interact to confer macroscopic mechanical...

... , “ Tensile Mechanical Properties of Three-Dimensional Type I Collagen Extracellular Matrices With Varied Microstructure ,” ASME J. Biomech. Eng. , 124 ( 2 ), pp. 214 – 222 . 10.1115/1.1449904 19 Wicker , B. K. , Hutchens , H. P. , Wu , Q. , Yeh , A. T. , and Humphrey , J. D...

... to model and predict the behavior under any load. Most ex vivo tests are performed within 24 h of dissection, so the tissue is still “alive.” For large elastic arteries; however, the passive mechanical behavior is attributed mostly to the very stable proteins, elastin, and collagen. If the testing...

... biological tissues biomechanics boundary-elements methods cellular biophysics deformation elasticity encapsulation finite element analysis optimisation Young's modulus osteoarthritis collagen proteoglycan aggrecan numerical model inverse problem Mow , V. C. , Ratcliffe...

...Thomas L. Willett; Rosalind S. Labow; Ian G. Aldous; Nick C. Avery; J. Michael Lee Soft tissue injuries are poorly understood at the molecular level. Previous work using differential scanning calorimetry (DSC) has shown that tendon collagen becomes less thermally stable with rupture. However, most...

...-00030 Iaconis , F. , Steindler , R. , and Marinozzi , G. , 1987 , “ Measurements of Cross-Sectional Area of Collagen Structures (Knee Ligaments) by Means of an Optical Method ,” J. Biomech. 0021-9290 , 20 ( 10 ), pp. 1003 – 1010 . 10.1016/0021-9290(87)90330-7 Woo , S...

... of their ability to differentiate into cells of the osteoblastic lineage. Mechanical stimulation is able to promote osteogenic differentiation of hMSC; however, the use of hydrostatic pressure (HP) has not been well studied. Artificial extracellular matrices containing collagen and chondroitin sulfate (CS) have...

... with arteries under normal pulsatile pressure. Porcine carotid arteries were cultured for 3 and 7 days under normal, nonpulsatile, and hyperpulsatile pressures with the same mean pressure and flow rate using an ex vivo organ culture model. Fenestrae in the internal elastic lamina, collagen, fibronectin, and gap...

... to be responsible for the initiation of the aneurysm growth. The aneurysm is regarded as a development of the adventitia, which is composed of several distinct layers of collagen fibers perfectly aligned in specified directions. The collagen fibers are the only load-bearing constituent in the aneurysm wall...