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research-article

Inhibition of contraction strength and frequency by wall shear stress in a single-lymphangion model

[+] Author and Article Information
C.D. Bertram

School of Mathematics & Statistics, University of Sydney, New South Wales, Australia 2006
c.bertram@sydney.edu.au

Charles Macaskill

School of Mathematics & Statistics, University of Sydney, New South Wales, Australia 2006
charlie.macaskill@sydney.edu.au

James E. Moore Jr.

Department of Bioengineering, Imperial College London, London SW7 2AZ, United Kingdom
james.moore.jr@imperial.ac.uk

1Corresponding author.

ASME doi:10.1115/1.4043724 History: Received February 26, 2019; Revised April 29, 2019

Abstract

The phasic contractions of collecting lymphatic vessels are reduced in strength and occur at diminished frequency when the favourable pressure difference and the resulting antegrade flow create large fluid shear stresses at the luminal surface. This paper describes a minimal phenomenological model of this mechanism, that is applied to a previously validated numerical model of a phasically contracting lymphangion. The parameters of the inhibition model are quantitatively matched to observations in isolated segments of rat lymphatic vessel, first for mesenteric lymphatics then for thoracic duct, and outcomes from the numerical model are then qualitatively compared with recent observations in isolated segments of rat thoracic duct.

Copyright (c) 2019 by ASME
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