Inhibition of contraction strength and frequency by wall shear stress in a single-lymphangion model

[+] Author and Article Information
C.D. Bertram

School of Mathematics & Statistics, University of Sydney, New South Wales, Australia 2006

Charles Macaskill

School of Mathematics & Statistics, University of Sydney, New South Wales, Australia 2006

James E. Moore Jr.

Department of Bioengineering, Imperial College London, London SW7 2AZ, United Kingdom

1Corresponding author.

ASME doi:10.1115/1.4043724 History: Received February 26, 2019; Revised April 29, 2019


The phasic contractions of collecting lymphatic vessels are reduced in strength and occur at diminished frequency when the favourable pressure difference and the resulting antegrade flow create large fluid shear stresses at the luminal surface. This paper describes a minimal phenomenological model of this mechanism, that is applied to a previously validated numerical model of a phasically contracting lymphangion. The parameters of the inhibition model are quantitatively matched to observations in isolated segments of rat lymphatic vessel, first for mesenteric lymphatics then for thoracic duct, and outcomes from the numerical model are then qualitatively compared with recent observations in isolated segments of rat thoracic duct.

Copyright (c) 2019 by ASME
Your Session has timed out. Please sign back in to continue.





Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In