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Technical Brief

Effect of Wall Elasticity on Hemodynamics and Wall Shear Stress in Patient-Specific Simulations in the Coronary Arteries

[+] Author and Article Information
Parastou Eslami

Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
peslami1@mgh.harvard.edu

Justin Tran

Department of Mechanical Engineering, Stanford University, Stanford, CA, USA
justntran@gmail.com

Zexi Jin

Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
zjin1@mgh.harvard.edu

Julia Karady

Department of Mechanical Engineering, Stanford University, Stanford, CA, USA
JKARADY@mgh.harvard.edu

Romina Sotoodeh

Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
romina.sotoodeh@mail.utoronto.ca

Michael T Lu

Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
mlu@mgh.harvard.edu

Udo Hoffmann

Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
uhoffmann@mgh.harvard.edu

Alison Marsden

Departments of Bioengineering and Pediatrics, Institute of Computational and Mathematical Engineering, Stanford University, Stanford, CA, USA
amarsden@stanford.edu

1Corresponding author.

ASME doi:10.1115/1.4043722 History: Received December 19, 2018; Revised April 24, 2019

Abstract

Wall shear stress (WSS) has been shown to be associated with myocardial infarction and progression of atherosclerosis. Wall elasticity is an important feature of hemodynamic modeling affecting WSS calculations. The objective of this study was to investigate the role of wall elasticity on WSS, and justify use of either rigid or elastic models in future studies. Digital anatomic models of the aorta and coronaries were created based on coronary computed tomography angiography (CCTA) in four patients. Hemodynamics were computed in rigid and elastic models using a finite element flow solver. WSS in five timepoints in the cardiac cycle and time averaged wall shear stress (TAWSS) were compared between the models at each 3mm subsegment and 4 arcs in cross sections along the centerlines of coronaries. In the left main, proximal left anterior descending, left circumflex and proximal right coronary artery of the elastic model, the mean percent radial increase were 5.95+/-1.25, 4.02+/-0.97, 4.08+/-0.94, 4.84+/-1.05%, respectively. WSS at each timepoint in the cardiac cycle had slightly different values, however when averaged over the cardiac cycle, there were negligible differences between the models. In both the subsegments (n=704) and sub-arc analysis, TAWSS in the two models were highly correlated (r=0.99) In investigation on the effect of coronary wall elasticity on WSS in CCTA-based models, the results of this study show no significant differences in TAWSS justifying using rigid wall models for future larger studies.

Copyright (c) 2019 by ASME
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