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In vivo Layer-specific Mechanical Characterization of Porcine Stomach Tissue using Ultrasound Elastography

[+] Author and Article Information
Saurabh Dargar

Center for Modeling, Simulation and Imaging in Medicine (CeMSIM), Rensselaer Polytechnic Institute, Troy, NY, USA; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA
dargas1@gmail.com

Rahul

Center for Modeling, Simulation and Imaging in Medicine (CeMSIM), Rensselaer Polytechnic Institute, Troy, NY, USA
pd.rahul@gmail.com

Uwe Kruger

Center for Modeling, Simulation and Imaging in Medicine (CeMSIM), Rensselaer Polytechnic Institute, Troy, NY, USA; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA
krugeu@rpi.edu

Suvranu De

Center for Modeling, Simulation and Imaging in Medicine (CeMSIM), Rensselaer Polytechnic Institute, Troy, NY, USA; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA; Department of Mechanical, Aerospace, and Nuclear Engineering, , Rensselaer Polytechnic Institute, Troy, NY, USA
des@rpi.edu

1Corresponding author.

ASME doi:10.1115/1.4043259 History: Received March 24, 2018; Revised March 04, 2019

Abstract

This paper presents in vivo mechanical characterization of the muscularis, submucosa and mucosa of the porcine stomach wall under large deformation loading. This is important for the development of gastrointestinal pathology-specific surgical intervention techniques. The study is based on testing the cardiac and fundic glandular stomach regions using a custom-developed compression elastography setup. Particular attention has been paid to elucidate the heterogeneity and anisotropy of tissue response. A Fung hyperelastic material model has been used to model the mechanical response of each tissue layer. A univariate analysis comparing the initial shear moduli of the three layers indicates that the muscularis (5.69±4.06 kPa) is the stiffest followed by the submucosa (3.04±3.32 kPa) and the mucosa (0.56±0.28 kPa). The muscularis is found to be strongly distinguishable from the mucosa tissue in the cardiac and fundic region based on a multivariate discriminant analysis. The cardiac muscularis is observed to be stiffer than the fundic muscularis tissue (shear moduli of 7.96±3.82 kPa vs. 3.42±2.96 kPa), more anisotropic (anisotropic parameter of 2.21±0.77 vs. 1.41±0.38), and strongly distinguishable from its fundic counterpart. Finally, a univariate comparison of the in vivo and ex vivo initial shear moduli for each layer shows that the muscularis and submucosa tissues are softer while in vivo, but the mucosa tissue is stiffer while in vivo. The mechanical properties highlight the inhomogeneity and anisotropy of multilayer stomach tissue.

Copyright (c) 2019 by ASME
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