Research Papers

Finite Element Modeling of Mitral Valve Repair

[+] Author and Article Information
Ashley E. Morgan

University of California,
San Francisco—East Bay Surgical Residency,
Oakland, CA 94602
e-mail: amorgan@alamedahealthsystem.org

Joe Luis Pantoja

School of Medicine,
University of California, San Francisco,
San Francisco, CA 94143
e-mail: Propantoja@gmail.com

Jonathan Weinsaft

Department of Cardiology,
Cornell University School of Medicine,
New York, NY 10065
e-mail: Jww2001@med.cornell.edu

Eugene Grossi

Department of Cardiothoracic Surgery,
NYU School of Medicine,
New York, NY 10016
e-mail: Eugene.grossi@nyumc.org

Julius M. Guccione

Department of Surgery and Bioengineering,
University of California, San Francisco,
San Francisco, CA 94143
e-mail: Julius.guccione@ucsf.edu

Liang Ge

Department of Surgery and Bioengineering,
Veterans Affairs Medical Center,
University of California, San Francisco,
San Francisco, CA 94121
e-mail: Liang.ge@gmail.com

Mark Ratcliffe

Surgical Service (112)
Departments of Surgery and Bioengineering,
Veterans Affairs Medical Center,
University of California, San Francisco,
4150 Clement Street,
San Francisco, CA 94121
e-mail: Mark.Ratcliffe@va.gov

1Corresponding author.

Manuscript received August 15, 2015; final manuscript received November 18, 2015; published online January 27, 2016. Editor: Victor H. Barocas.

J Biomech Eng 138(2), 021009 (Jan 27, 2016) (8 pages) Paper No: BIO-15-1408; doi: 10.1115/1.4032125 History: Received August 15, 2015; Revised November 18, 2015

The mitral valve is a complex structure regulating forward flow of blood between the left atrium and left ventricle (LV). Multiple disease processes can affect its proper function, and when these diseases cause severe mitral regurgitation (MR), optimal treatment is repair of the native valve. The mitral valve (MV) is a dynamic structure with multiple components that have complex interactions. Computational modeling through finite element (FE) analysis is a valuable tool to delineate the biomechanical properties of the mitral valve and understand its diseases and their repairs. In this review, we present an overview of relevant mitral valve diseases, and describe the evolution of FE models of surgical valve repair techniques.

Copyright © 2016 by ASME
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Grahic Jump Location
Fig. 1

(a) Intraoperative image of floppy valve with “flail” posterior segment: AL = anterior leaflet, PL = posterior leaflet. (b) Intraoperative image of subvalvular apparatus demonstrating chordae and papillary muscles. (c) Intraoperative image of repaired and reshaped mitral valve.

Grahic Jump Location
Fig. 2

(a) 2D echocardiogram of MR secondary to isolated prolapse of the center segment of the posterior leaflet (P2), with color image showing regurgitant blood flow. (b) Echocardiogram of patient with functional MR, showing normal valve leaflets and regurgitant flow of blood. (c) Mitral valve after surgical repair, showing normal leaflet coaptation and no regurgitant flow of blood.

Grahic Jump Location
Fig. 3

Wenk model of LV + MV [40]. (a) Exterior view of the LV showing postero-basal MI. (b) Interior view of LV with chordae connected to the papillary muscles.

Grahic Jump Location
Fig. 4

Ge model of human LV + M V with P2 prolapse [43]

Grahic Jump Location
Fig. 5

FE simulation of triangular resection of P2 prolapse and annuloplasty [43]. (a) Pre-operative model showing prolapse of the P2 leaflet. (b) After triangular resection of the P2 section of the posterior leaflet. (c) Postoperative model in early diastole. (d) Postoperative model at end-systole with valve closed.

Grahic Jump Location
Fig. 6

PPM anchoring suture placed between the PPM and either the AC, PC, or the CP [46]



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