Research Papers

How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation

[+] Author and Article Information
Eimear B. Dolan

Biomechanics Research Centre (BMEC),
Biomedical Engineering,
NUI Galway, Ireland
e-mail: e.dolan4@nuigalway.ie

Ted J. Vaughan

Biomechanics Research Centre (BMEC),
Biomedical Engineering,
NUI Galway, Ireland
e-mail: ted.vaughan@nuigalway.ie

Glen L. Niebur

Department of Aerospace
and Mechanical Engineering,
University of Notre Dame,
Notre Dame, IN 46556
e-mail: gniebur@nd.edu

Conor Casey

Stryker Ireland,
Carrigtwohill, Cork, Ireland
e-mail: Conor.casey@stryker.com

David Tallon

Stryker Ireland,
Carrigtwohill, Cork, Ireland
e-mail: David.tallon@stryker.com

Laoise M. McNamara

Biomechanics Research Centre (BMEC),
Biomedical Engineering,
NUI Galway, Ireland
e-mail: Laoise.mcnamara@nuigalway.ie

1Corresponding author.

Contributed by the Bioengineering Division of ASME for publication in the Journal of Biomechanical Engineering. Manuscript received August 13, 2013; final manuscript received November 27, 2013; accepted manuscript posted December 9, 2013; published online February 5, 2014. Editor: Victor H. Barocas.

J Biomech Eng 136(2), 021019 (Feb 05, 2014) (9 pages) Paper No: BIO-13-1362; doi: 10.1115/1.4026177 History: Received August 13, 2013; Revised November 27, 2013; Accepted December 09, 2013

During orthopaedic surgery elevated temperatures due to cutting can result in bone injury, contributing to implant failure or delayed healing. However, how resulting temperatures are experienced throughout bone tissue and cells is unknown. This study uses a combination of experiments (forward-looking infrared (FLIR)) and multiscale computational models to predict thermal elevations in bone tissue and cells. Using multiple regression analysis, analytical expressions are derived allowing a priori prediction of temperature distribution throughout bone with respect to blade geometry, feed-rate, distance from surface, and cooling time. This study offers an insight into bone thermal behavior, informing innovative cutting techniques that reduce cellular thermal damage.

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Alam, K., Mitrofanov, A. V., and Silberschmidt, V. V., 2009, “Finite Element Analysis of Forces of Plane Cutting of Cortical Bone,” Comput. Mater. Sci., 46(3), pp. 738–743. [CrossRef]
Alam, K., Mitrofanov, A. V., and Silberschmidt, V. V., 2010, “Thermal Analysis of Orthogonal Cutting of Cortical Bone Using Finite Element Simulations,” Int. J. Exp. Comput. Biomech., 1(3), pp. 236–251. [CrossRef]
Karmani, S., 2006, “The Thermal Properties of Bone and the Effects of Surgical Intervention.” Curr. Orthop., 20(1), pp. 52–58. [CrossRef]
Krause, W. R., Bradbury, D. W., Kelly, J. E., and Lunceford, E. M., 1982, “Temperature Elevations in Orthopaedic Cutting Operations,” J. Biomech., 15(4), pp. 267–275. [CrossRef] [PubMed]
Li, S., Chien, S., and Brånemark, P.-I., 1999, “Heat Shock-Induced Necrosis and Apoptosis in Osteoblasts,” J. Orthop. Res., 17(6), pp. 891–899. [CrossRef] [PubMed]
Lundskog, J., 1972, “Heat and Bone Tissue. An Experimental Investigation of the Thermal Properties of Bone and Threshold Levels for Thermal Injury,” Scand. J. Plast. Reconstr. Surgery, 9: pp. 1–80.
Eriksson, A., Albrektsson, T., Grane, B., and McQueen, D., 1982, “Thermal Injury to Bone: A Vital-Microscopic Description of Heat Effects,” Int. J. Oral Surg., 11(2), pp. 115–121. [CrossRef] [PubMed]
Eriksson, A. R. and Albrektsson, T., 1983, “Temperature Threshold Levels for Heat-Induced Bone Tissue Injury: A Vital-Microscopic Study in the Rabbit,” J. Prosthet. Dent., 50, pp. 101–106. [CrossRef] [PubMed]
Eriksson, A. R., Albrektsson, T., and Magnusson, B., 1984, “Assessment of Bone Viability After Heat Trauma: A Histological, Histochemical and Vital Microscopic Study in the Rabbit,” Scand. J. Plast. Reconstr. Surg. Hand Surg., 18(3), pp. 261–268. [CrossRef]
Leucht, P., Lam, K., Kim, J-B., Mackanos, M. A., Simanovskii, D. M., Longaker, M. T., Contag, C. H., Schwettman, H. A., and Helms, J. A., 2007, “Accelerated Bone Repair After Plasma Laser Corticotomies,”Ann. Surg, 246(1), pp. 140–150. [CrossRef] [PubMed]
Stelzle, F., Frenkel, C., Riemann, M., Knipfer, C., Stockmann, P., and Nkenke, E., 2012, “The Effect of Load on Heat Production, Thermal Effects and Expenditure of Time During Implant Site Preparation—An Experimental Ex Vivo Comparison Between Piezosurgery and Conventional Drilling,” Clin. Oral Implants Res., pp. 1–9.
Albrektsson, T., Brånemark, P., Hansson, H. A., and Lindström, J., 1981, “Osseointegrated Titanium Implants: Requirements for Ensuring a Long-Lasting, Direct Bone-to-Implant Anchorage in Man,” Acta Orthop., 52(2): pp. 155–170. [CrossRef]
Albrektsson, T., 1980, “The Healing of Autologous Bone Grafts After Varying Degrees of Surgical Trauma. A Microscopic and Histochemical Study in the Rabbit” J Bone Jt. Surg., Br. Vol., 62-B(3), pp. 403–410.
Dolan, E. B., Haugh, M. G., Tallon, D., Casey, C., and McNamara, L. M., 2012, “Heat-Shock-Induced Cellular Responses to Temperature Elevations Occurring During Orthopaedic Cutting,” J. R. Soc., Interface, 9(77), pp. 3503–3513.
Vaughan, T. J., McCarthy, C. T., and McNamara, L. M., 2012, “A Three-Scale Finite Element Investigation Into the Effects of Tissue Mineralisation and Lamellar Organisation in Human Cortical and Trabecular Bone,” J. Mech. Beh. Biomed. Mater., 12, pp. 50–62. [CrossRef]
Vaughan, T. J., and McNamara, L. M., 2012, “Multiscale Modelling of Bone: Understanding Tissue Mechanics and Cell Mechanobiology,” J. Biomech., 45, p. S473. [CrossRef]
Hillery, M. T., and Shuaib, I., 1999, “Temperature Effects in the Drilling of Human and Bovine Bone,” J. Mater. Process. Technol., 92-93, pp. 302–308. [CrossRef]
Sharawy, M., Misch, C. E., Weller, N., and Tehemar, S., 2002, “Heat Generation During Implant Drilling: The Significance of Motor Speed,” J. Oral Maxillofac. Surg., 60(10), pp. 1160–1169. [CrossRef] [PubMed]
Davidson, S. R. H., and James, D. F., 2000, “Measurement of Thermal Conductivity of Bovine Cortical Bone,” Med. Eng. Phys., 22(10), pp. 741–747. [CrossRef] [PubMed]
Augustin, G., Davila, S., Mihoci, K., Udiljak, T., Vedrina, D. S., and Antabak, A., 2008, “Thermal Osteonecrosis and Bone Drilling Parameters Revisited,” Arch. Orthop. Trauma Surg., 128(1), pp. 71–77. [CrossRef] [PubMed]
Sugita, N., Osa, T., and Mitsuishi, M., 2009, “Analysis and Estimation of Cutting-Temperature Distribution During End Milling in Relation to Orthopedic Surgery,” Med.Eng. Phys., 31(1), pp. 101–107. [CrossRef] [PubMed]
Baker, R., Whitehouse, M., Kilshaw, M., Pabbruwe, M., Spencer, R., Blom, A., and Bannister, G., 2011, “Maximum Temperatures of 89 °C Recorded During the Mechanical Preparation of 35 Femoral Heads for Resurfacing,” Acta Orthop., 82(6), pp. 669–673. [CrossRef] [PubMed]
Dinwiddie, R. B., and Steffner, T. E., 2007, “Thermal Imaging of Medical Saw Blades and Guides, InfraMation Infrared Camera Applications Conference, 2007, Las Vegas, NV. October 15–19, pp. 245–254.
Augustin, G., Davila, S., Udiljak, T., Vedrina, D. S., and Bagatin, D., 2009, “Determination of Spatial Distribution of Increase in Bone Temperature During Drilling by Infrared Thermography: Preliminary Report,” Arch. Orthop. Trauma Surg., 129(5), pp. 703–709. [CrossRef] [PubMed]
Lee, J., Rabin, Y., and Ozdoganlar, O. B., 2011, “A New Thermal Model for Bone Drilling With Applications to Orthopaedic Surgery,” Med. Eng. Phys., 33(10), pp. 1234–1244. [CrossRef] [PubMed]
Eriksson, R. A., and Albrektsson, Y., 1984, “The Effect of Heat on Bone Regeneration: An Experimental Study in the Rabbit Using the Bone Growth Chamber,” J. Oral Maxillofac. Surg., 42(11), pp. 705–711. [CrossRef] [PubMed]
Kennedy, O. D., 2007, “The Effect of Bone Turnover on Bone Quality and Material Properties,” Trinity College Dublin, Dublin.
Karaca, F., Aksakal, B., and Kom, M., 2011, “Influence of Orthopaedic Drilling Parameters on Temperature and Histopathology of Bovine Tibia: An In Vitro Study,” Med. Eng. Phys., 33(10), pp. 1221–1227. [CrossRef] [PubMed]
Stumme, L. D., Baldini, T. H., Jonassen, E. A., and Bach, J. M., 2003, “Emissivity of Bone,” Summer Bioengineering Conference, 2003, Key Biscayne, FL, June 25–29, pp. 1013–1014.
Bialkowski, S. E., 1996, Photothermal Spectroscopy Methods for Chemical Analysis, Vol. 134, Wiley, New York.
Dada, O. O., Feist, P. E., and Dovichi, N. J., 2011, “Thermal Diffusivity Imaging With the Thermal Lens Microscope,” Appl. Opt., 50(34), pp. 6336–6342. [CrossRef] [PubMed]
Vaughan, T. J., Verbruggen, S. W., and McNamara, L. M., 2013, “Are All Osteocytes Equal? Multiscale Modelling of Cortical Bone to Characterise the Mechanical Stimulation of Osteocytes,” Int. J. Numerical Methods Biomed. Eng., 29(12), pp. 1361–1372. [CrossRef]
Particelli, F., Mecozzi, L., Beraudi, A., Montesi, M., Baruffaldi, F., and Viceconti, M., 2012, “A Comparison Between Micro-CT and Histology for the Evaluation of Cortical Bone: Effect of Polymethylmethacrylate Embedding on Structural Parameters,” J. Microsc., 245(3), p. 302–310. [CrossRef] [PubMed]
Verbruggen, S. W., Vaughan, T. J., and McNamara, L. M., 2012, “Strain Amplification in Bone Mechanobiology: A Computational Investigation of the In Vivo Mechanics of Osteocytes,” J. R. Soc., Interface, 9(75), pp. 2735–2744. [CrossRef]
Lin, Y. and Xu, S., 2011, “AFM Analysis of the Lacunar-Canalicular Network in Demineralized Compact Bone,” J. Microsc., 241(3), p. 291–302. [CrossRef] [PubMed]
Rockwood, C. A., Bucholz, R. W., Court-Brown, C. M., Heckman, J. D., and Tornetta, P., 2006, Rockwood and Green's Fractures in Adults, Lippincott Williams and Wilkins, Philadelphia, PA.
Morris, M. and Kelly, P., 1980, “Use of Tracer Microspheres to Measure Bone Blood Flow in Conscious Dogs,” Calcif. Tissue Int., 32(1), pp. 69–76. [CrossRef] [PubMed]
Reichert, I., McCarthy, I., and Hughes, S., 1995, “The Acute Vascular Response to Intramedullary Reaming. Microsphere Estimation of Blood Flow in the Intact Ovine Tibia,” J. Bone Jt. Surg., Br. Vol., 77–B(3), pp. 490–493.
Davidson, S. R. H., and James, D. F., 2003, “Drilling in Bone: Modeling Heat Generation and Temperature Distribution,” ASME J. Biomech. Eng., 125(3), pp. 305–314, 2003. [CrossRef]
Augustina, G., Zigmana, T., Davilaa, S., Udilljakb, T., Staroveskib, T., Brezakb, D., and Babic, S., “Cortical Bone Drilling and Thermal Osteonecrosis,” Clin. Biomech., 27(4), pp. 313–325. [CrossRef]
Sugita, N., Osa, T., Aoki, R., and Mitsuishi, M., 2009, “A New Cutting Method for Bone Based on Its Crack Propagation Characteristics,” CIRP Ann., 58(1), pp. 113–118. [CrossRef]
Rath Bonivtch, A., Bonewald, L. F., and Nicolella, D. P., 2007, “Tissue Strain Amplification at the Osteocyte Lacuna: A Microstructural Finite Element Analysis,” J. Biomech., 40(10), pp. 2199–2206. [CrossRef] [PubMed]
Mulcahy, L. E., Taylor, D., Lee, T. C., and Duffy, G. P., 2011, “RANKL and OPG Activity is Regulated by Injury Size in Networks of Osteocyte-Like Cells,” Bone, 48(2), pp. 182–188. [CrossRef] [PubMed]
Kennedy, O. D., Herman, B. C., Laudier, D. M., Majeskaa, R. J., Sun, H. B., and Schaffler, M. B., 2012, “Activation of Resorption in Fatigue-Loaded Bone Involves Both Apoptosis and Active Pro-Osteoclastogenic Signaling by Distinct Osteocyte Populations,” Bone, 50(5), pp. 1115–1122. [CrossRef] [PubMed]
Chato, J. C., 1990, Fundamentals of Bioheat Transfer, Thermal Dosimetry and Treatment Planning, Springer Berlin Heidelberg. [CrossRef]
Clauser, C. E., McConville, J. T., and Young, J. W., 1969, “Weight, Volume, and Center of Mass of Segments of the Human Body,” Aerospace Medical Research Laboratory, Aerospace Medical Division, Air Force Systems Command, Wright-Patterson Air Force Base, Ohio.
McIntosh, R. L., and Anderson, V., 2010, “A Comprehensive Tissue Properties Database Provided for the Thermal Assessment of a Human at Rest,” Biophys. Rev. Lett., 5(03), pp. 129–151. [CrossRef]
Woodard, H. Q., and White, D. R., “The Composition of Body Tissues,” Br. J. Radiol., 59(708), pp. 1209–1218. [CrossRef] [PubMed]
Challoner, A. R., and Powell, R. W., 1956, “Thermal Conductivities of Liquids: New Determinations for Seven Liquids and Appraisal of Existing Values,” Proc. R. Soc. London, Ser. A, 238(1212), pp. 90–106. [CrossRef]
Kell, G. S., 1967, “Precise Representation of Volume Properties of Water at One Atmosphere,” J. Chem. Eng. Data, 12(1), pp. 66–69. [CrossRef]
Manya, J. J., Antal, M. J., Jr., Kinoshita, C. K., and Masutani, S. M., 2011, “Specific Heat Capacity of Pure Water at 4.0 MPa between 298.15 and 465.65 K,” Ind. Eng. Chem. Res., 50(10), pp. 6470–6484. [CrossRef]


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Fig. 1

Experimental setup of ovine metatarsal clamped and cut with heavy duty surgical saw (left), and imaged using a FLIR thermal imaging technology (right) for the measurement of thermal elevations immediately after cutting. The white arrows represent torn periosteum on the surface of the specimen, the black circle is the cortical bone boundary, and the white circle is the marrow cavity.

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Fig. 2

Thermal lens microscopy of bovine cortical bone: (a) transmission image, and (b) thermal diffusivity plot where the scale is the thermal diffusivity (10−7 m2/s) and the area around a single cell (c) with cellular component, (d) with cellular material removed, and (e) with the area of low thermal diffusivity adjacent to the cell removed. Scale bar = 20 μm.

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Fig. 3

Multiscale modeling approach where the surface heat flux was applied to the global model (as indicated by broken arrows) based on the experimental investigation. The resulting nodal thermal elevations are applied to the more detailed geometry of the osteon and osteocyte submodels (described in Section 2.3).

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Fig. 4

Temperature elevations observed, experimentally and computationally, modeled on the cut bone surface as a result of 15 s continuous cutting at 150 mm/min and 40 s continuous cutting at 50 mm/min for 2 oscillating surgical saw blades

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Fig. 5

Global model of thermal elevations throughout the cortical bone component at six different locations for (a) blade A and (b) blade B at the 150 mm/min feed rate, and (c) blade A and (d) blade B at the 50 mm/min feed rate

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Fig. 6

Global model of the thermal distribution throughout bone tissue at the maximum temperature elevation for (a) blade A and (b) blade B at the 150 mm/min feed rate, and (c) blade A and (d) blade B at the 50 mm/min feed rate

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Fig. 7

Osteon submodel (a) demonstrating the dissipation of heat to the embedded cells (b), through cortical bone at 15 s. Cells located at surface, 75 μm and 150 μm back from the heated surface in the z-direction. The osteocyte lacuna submodel demonstrated the flow of heat into the embedded cell (c).



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