Research Papers

Computational Analysis of Non-Spherical Particle Transport and Deposition in Shear Flow With Application to Lung Aerosol Dynamics—A Review

[+] Author and Article Information
Clement Kleinstreuer

Department of Mechanical and Aerospace Engineering,
North Carolina State University,
Raleigh, NC 27695-7910;
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and NC State University,
Raleigh, NC 27695-7910
e-mail: ck@ncsu.edu

Yu Feng

Department of Mechanical and Aerospace Engineering,
North Carolina State University,
Raleigh, NC 27695-7910

1Corresponding author.

Contributed by the Bioengineering Division of ASME for publication in the Journal of Biomechanical Engineering. Manuscript received November 9, 2012; final manuscript received December 3, 2012; accepted manuscript posted December 22, 2012; published online February 7, 2013. Editor: Victor H. Barocas.

J Biomech Eng 135(2), 021008 (Feb 07, 2013) (19 pages) Paper No: BIO-12-1547; doi: 10.1115/1.4023236 History: Received November 09, 2012; Revised December 03, 2012

All naturally occurring and most man-made solid particles are nonspherical. Examples include air-pollutants in the nano- to micro-meter range as well as blood constituents, drug particles, and industrial fluid-particle streams. Focusing on the modeling and simulation of inhaled aerosols, theories for both spherical and nonspherical particles are reviewed to analyze the contrasting transport and deposition phenomena of spheres and equivalent spheres versus ellipsoids and fibers.

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Fig. 1

Estimated number of 2012 deaths caused by different cancers in the United States [1]

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Fig. 2

Deaths for the ten leading causes of deaths in all ages of the United States in 2010 [2]

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Fig. 3

Two-dimensional finite-element mesh in channel flow using the ALE method [66]

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Fig. 4

Fixed triangular grid used in DLM computations [65]

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Fig. 5

Incidence angle αi of nonspherical particle

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Fig. 6

The rotations defining the Euler angles [87]

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Fig. 7

Coordinate systems for nonspherical particle modeling

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Fig. 8

Euler angles between coordinate x′y′z′ and coordinate x′′y′′z′′

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Fig. 9

Saffman lift force for a particle in linear shear flow

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Fig. 10

Total deposition efficiency comparisons between spherical particles and ellipsoidal particles with different aspect ratios in a subject-specific lung airway model [86]



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