Technical Briefs

System and Method for Investigating Arterial Remodeling

[+] Author and Article Information
Alexander Rachev

Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332alexander.rachev@me.gatech.edu

Zachary Dominguez, Raymond Vito

Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332

J Biomech Eng 131(10), 104501 (Sep 10, 2009) (3 pages) doi:10.1115/1.3207014 History: Received November 13, 2008; Revised June 30, 2009; Published September 10, 2009

Organ culture systems are used to study remodeling of arteries and to fabricate tissue engineered vascular grafts. Investigations to date focused on changes in geometry and mechanical response of arteries or constructs associated with controlled sustained alterations in the global load parameters such as the arterial pressure, flow, or axial stretch. A new experimental paradigm is proposed, which is based on the simultaneous independent control of local mechanical parameters such as mean strain or stress in the arterial wall and flow-induced shear at the intima. An organ culture system and methodology were developed, which controls pressure, flow, and axial length of a specimen in order to maintain the local mechanical parameters at prescribed values. The operation of the system is illustrated by maintenance of elevated axial medial stress in porcine carotid artery, while keeping the mean circumferential stress and flow-induced shear stress at baseline values. Previously unknown aspects of remodeling that might be revealed by the novel approach are discussed.

Copyright © 2009 by American Society of Mechanical Engineers
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Grahic Jump Location
Figure 1

Schematic of the organ culture system

Grahic Jump Location
Figure 2

Schematic diagram of the algorithm and process used to set and maintain values of the local mechanical variables: The subscripts “e” and “c” refer to the current experimentally recorded and calculated approximate values of the global mechanical parameters, respectively

Grahic Jump Location
Figure 3

Time course of circumferential stress (dotted line), axial stress (solid line), and flow-induced shear stress (dashed curve)—(a) during first 3.5 h of experiment and (b) during 7 days in organ culture—where they are normalized by their target values



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