Research Papers

An Adjustable Triple-Bifurcation Unit Model for Air-Particle Flow Simulations in Human Tracheobronchial Airways

[+] Author and Article Information
C. Kleinstreuer1

Department of Mechanical and Aerospace Engineering, and Department of Biomedical Engineering, North Carolina State University, Raleigh NC 27695-7910ck@eos.ncsu.edu

Z. Zhang

Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh NC 27695-7910



Corresponding author.

J Biomech Eng 131(2), 021007 (Dec 10, 2008) (10 pages) doi:10.1115/1.3005339 History: Received March 27, 2008; Revised August 20, 2008; Published December 10, 2008

A new methodology for a swift and accurate computer simulation of large segments of the human lung airways is presented. Focusing on a representative tracheobronchial (TB) region, i.e., G0–G15, nano- and micron particle transports have been simulated for Qin=30lmin, employing an experimentally validated computer model. The TB tree was geometrically decomposed into triple-bifurcation units with kinematically adjusted multilevel outlet/inlet conditions. Deposition patterns and maximum concentrations differ greatly between nanoparticles (1dp150nm) and micron particles (1dp10μm), which may relate uniquely to health impacts. In comparison with semi-analytical particle deposition results, it is shown that such simple “lung models” cannot predict local deposition values but can match computer simulation results for the entire TB region within 2.5–26%. The present study revealed that turbulent air-particle flow may propagate to G5 for the assumed inhalation flow rate. Geometry and upstream effects are more pronounced for micron particle deposition than for nanoparticle deposition.

Copyright © 2009 by American Society of Mechanical Engineers
Your Session has timed out. Please sign back in to continue.



Grahic Jump Location
Figure 1

Models of human tracheobronchial (TB) airways. The dashed lines indicate the segmental boundaries for bifurcations.

Grahic Jump Location
Figure 2

Flow diagram for particle deposition simulations in TB airways using triple-bifurcation units (TBUs)

Grahic Jump Location
Figure 3

Comparison of TB deposition fractions between the present simulations and experimental measurements

Grahic Jump Location
Figure 4

Typical airflow structures (Q=30l∕min)

Grahic Jump Location
Figure 5

Distributions of turbulent kinetic energy (Q=30l∕min)

Grahic Jump Location
Figure 6

Distributions of nanoparticle deposition enhancement factor (DEF) (Q=30l∕min and dp=10nm)

Grahic Jump Location
Figure 7

Distributions of micron particle DEF (Q=30l∕min and dp=10μm)



Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In