TECHNICAL PAPERS: Fluids/Heat/Transport

A Mechanistic Model for Quasistatic Pulmonary Pressure-Volume Curves for Inflation

[+] Author and Article Information
R. Amini, K. Creeden, U. Narusawa

Department of Mechanical and Industrial Engineering, Northeastern University, Boston, Massachusetts 02115

J Biomech Eng 127(4), 619-629 (Feb 22, 2005) (11 pages) doi:10.1115/1.1934079 History: Received April 21, 2004; Revised February 22, 2005

A mechanistic model of the respiratory system is proposed to understand differences in quasistatic pressure-volume (p-V) curves of the inflation process in terms of the alveolar recruitment and the elastic distension of the wall tissues. In the model, a total respiratory system consists of a large number of elements, each of which is a subsystem of a cylindrical chamber fitted with a piston attached to a spring. The alveolar recruitment is simulated by allowing a distribution of the critical pressure at which an element opens; while the wall distension is represented by the piston displacement. Relations are derived between parameters in the error-function p-V model equation and properties of the mechanistic model. The parameters of the model-based p-V equation are determined for clinical data sets of patients with acute respiratory distress syndrome.

Copyright © 2005 by American Society of Mechanical Engineers
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Figure 1

(a) A typical quasistatic pulmonary pressure-volume curve, (b) V(p) vs Vp(p)

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Figure 2

Error-function p-V equation and inflation data points

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Figure 3

A schematic diagram of mechanistic model of TRS element

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Figure 4

V (volume predicted by model-based p-V equation) vs V (volume of data) for a specified pressure

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Figure 5

Model-based p-V equation, Eq. 13, vs data points for inflation process. Solid: solution for low-pressure region; dotted: solution for high-pressure region.

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Figure 6

Data points for inflation (unfilled) and deflation (filled). p-V equation of mechanistic model for inflation (I) and the error function p-V equation for deflation (D).

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Figure 7

VUd (predicted from the mechanistic model) vs VUd (of error-function p-V equation for deflation)



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