Mechanical Analysis of Heterogeneous, Atherosclerotic Human Aorta

[+] Author and Article Information
D. Beattie, R. Vito, M. C. Whang

George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332

C. Xu, S. Glagov

Department of Pathology, University of Chicago, Chicago, IL 60637

J Biomech Eng 120(5), 602-607 (Oct 01, 1998) (6 pages) doi:10.1115/1.2834750 History: Received November 25, 1997; Revised March 17, 1998; Online January 23, 2008


An experimental technique was developed to determine the finite strain field in heterogeneous, diseased human aortic cross sections at physiologic pressures in vitro. Also, the distributions within the cross sections of four histologic features (disease-free zones, lipid accumulations, fibrous intimal tissue, and regions of calcification) were quantified using light microscopic morphometry. A model incorporating heterogeneous, plane stress finite elements coupled the experimental and histologic data. Tissue constituent mechanical properties were determined through an optimization strategy, and the distributions of stress and strain energy in the diseased vascular wall were calculated. Results show that the constituents of atherosclerotic lesions exhibit large differences in their bilinear mechanical properties. The distributions of stress and strain energy in the diseased vascular wall are strongly influenced by both lesion structure and composition. These results suggest that accounting for heterogeneities in the mechanical analysis of atherosclerotic arterial tissue is critical to establishing links between lesion morphology and the susceptibility of plaque to mechanical disruption in vivo.

Copyright © 1998 by The American Society of Mechanical Engineers
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