Effect of Intraluminal Thrombus Thickness and Bulge Diameter on the Oxygen Diffusion in Abdominal Aortic Aneurysm

[+] Author and Article Information
D. A. Vorp

Department of Surgery, Department of Mechanical Engineering, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213

D. H. J. Wang

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213

M. W. Webster

Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213

W. J. Federspiel

Department of Surgery, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213

J Biomech Eng 120(5), 579-583 (Oct 01, 1998) (5 pages) doi:10.1115/1.2834747 History: Received April 25, 1997; Revised February 07, 1998; Online January 23, 2008


The intraluminal thrombus (ILT) commonly found within abdominal aortic aneurysm (AAA) may serve as a barrier to oxygen diffusion from the lumen to the inner layers of the aortic wall. The purpose of this work was to address this hypothesis and to assess the effects of AAA bulge diameter (dAAA ) and ILT thickness (δ) on the oxygen flow. A hypothetical, three-dimensional, axisymmetric model of AAA containing ILT was created for computational analysis. Commercial software was utilized to estimate the volume flow of O2 per cell, which resulted in zero oxygen tension at the AAA wall. Solutions were generated by holding one of the two parameters fixed while varying the other. The supply of O2 to the AAA wall increases slightly and linearly with dAAA for a fixed δ. This slight increase is due to the enlarged area through which diffusion of O2 may take place. The supply of O2 was found to decrease quickly with increasing δ for a fixed dAAA due to the increased resistance to O2 transport by the ILT layer. The presence of even a thin, 3 mm ILT layer causes a diminished O2 supply (less than 4 × 10−10 μmol/min/cell). Normally functioning smooth muscle cells require a supply of 21 × 10−10 μmol/min/cell. Thus, our analysis serves to support our hypothesis that the presence of ILT alters the normal pattern of O2 supply to the AAA wall. This may lead to hypoxic cell dysfunction in the AAA wall, which may further lead to wall weakening and increased potential for rupture.

Copyright © 1998 by The American Society of Mechanical Engineers
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