Heat-Induced Changes in the Mechanics of a Collagenous Tissue: Isothermal Free Shrinkage

[+] Author and Article Information
S. S. Chen, N. T. Wright, J. D. Humphrey

Department of Mechanical Engineering, The University of Maryland, Baltimore, MD 21250

J Biomech Eng 119(4), 372-378 (Nov 01, 1997) (7 pages) doi:10.1115/1.2798281 History: Received February 07, 1996; Revised December 17, 1996; Online October 30, 2007


We present data from isothermal free-shrinkage tests (i.e., performed in the absence of mechanical loads) wherein bovine chordae tendineae were subjected to temperatures from 65 to 85°C for 120 to 1200 s. These data reveal four new insights into heat-induced denaturation of a collagenous tissue. First, a characteristic time for the free shrinkage appears to exhibit an Arrhenius-type relationship with temperature. Second, scaling the actual heating time via the characteristic time results in a single correlation between free shrinkage and the duration of heating; this correlation suggests a time-temperature equivalence. Third, it is the cumulative, not current, heating time that governs the free shrinkage. And fourth, heat-induced free shrinkage is partially recovered when the tissue is returned to 37°C, this recovery also being time-dependent. Although these findings will help guide future experimentation and constitutive modeling, as well as the design of new heat-based clinical therapies, there is a pressing need to collect additional isothermal data, particularly in the presence of well-defined mechanical loads.

Copyright © 1997 by The American Society of Mechanical Engineers
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