The Effects of Cardiac Infarction on Realistic Three-Dimensional Left Ventricular Blood Ejection

[+] Author and Article Information
Tad W. Taylor, Haruka Okino, Takami Yamaguchi

Department of Bio-Medical Engineering, School of High-Technology for Human Welfare, Tokai University, 317 Nishino, Numazu, Shizuoka 410-03 Japan

Hiroyuki Suga

The 2nd Department of Physiology, Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700 Japan

Yoichi Goto

National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565 Japan

J Biomech Eng 118(1), 106-110 (Feb 01, 1996) (5 pages) doi:10.1115/1.2795934 History: Received April 25, 1993; Revised January 25, 1995; Online October 30, 2007


The effect of cardiac infarction on the flow patterns in cardiac left ventricular ejection was studied using a realistic model which was made from the profile of the left ventricle of a dog heart in diastole. A Coordinate measuring machine was used to measure the left ventricular coordinates, and these were input into a three-dimensional flow simulation package. The left ventricular wall motion was described by having the walls moved towards the center of the aortic outlet, and in the case of infarcted tissue, the ventricular wall movement was diminished to simulate infarction flow behavior. The final ventricular volume varied from 25 percent to 54.1 percent of the initial volume in cases without and with infarction, respectively. The maximum blood ejection velocities and ventricular pressure decreased significantly in the presence of infarction. Infarcted areas showed complex blood flow vortex formation not present in the healthy ventricles. The Computational technique presented here predicts infarction flow effects which could be observed with measurement techniques such as ultrasound and magnetic resonance imaging, allowing a finer detail of understanding than using either simulation or experimental measurements alone.

Copyright © 1996 by The American Society of Mechanical Engineers
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