Flow Rate-Pressure Drop Relation in Coronary Angioplasty: Catheter Obstruction Effect

[+] Author and Article Information
L. H. Back, E. Y. Kwack

Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109

M. R. Back

Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA 90509

J Biomech Eng 118(1), 83-89 (Feb 01, 1996) (7 pages) doi:10.1115/1.2795949 History: Received March 20, 1994; Revised November 04, 1994; Online October 30, 2007


Quantitative methods to measure the hemodynamic consequences of various endovascular interventions including balloon angioplasty are limited. Catheters measuring translesional pressure drops during balloon angioplasty procedures can cause flow blockage and thus inaccurate estimates of pre- and post-intervention flow rates. The purpose of this investigation was to examine the influence of the presence and size of an angioplasty catheter on measured mean pressure gradients across human coronary artery stenoses. Analytical flow modeling and in vitro experimental evidence, coupled with angiographic data on the dimensions and shape of stenotic vessel segments before and after angioplasty, indicated significant flow blockage effects with the catheter present.

Copyright © 1996 by The American Society of Mechanical Engineers
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