Hemolytic Potential of Hydrodynamic Cavitation

[+] Author and Article Information
Sean D. Chambers

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48103e-mail: chambers@mc3corp.com

Robert H. Bartlett

Department of Surgery, University of Michigan, Ann Arbor, MI 48103

Steven L. Ceccio

Department of Mechanical Engineering and Applied Mechanics, University of Michigan, Ann Arbor, MI 48103

J Biomech Eng 122(4), 321-326 (Jan 05, 2000) (6 pages) doi:10.1115/1.1286560 History: Received September 03, 1998; Revised January 05, 2000
Copyright © 2000 by ASME
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Grahic Jump Location
Schematic of the single-pass experimental apparatus: Cavitation Susceptibility Meter (CSM), syringe pump (SP), differential pressure transducer (DPT), gage pressure transducer (GPT), three-way ball valve for priming apparatus (BV), collection chamber (CC), pressure vessel (PV), vacuum source (VS), acoustic counter (AC).
Grahic Jump Location
Mechanical drawing of the Cavitation Susceptibility Meter (CSM) with units in millimeters. The CSM was constructed by an electroplating technique. The inner surface is gold and the structure is copper.
Grahic Jump Location
Schematic of the recirculating flow apparatus: bubble trap (BT), centrifugal pump (CP), Cavitation Susceptibility Meter (CSM), acoustic counter (AC), differential pressure transducer (DPT), gage pressure transducer (GPT), heat exchanger (HE).
Grahic Jump Location
Comparison of the measured inlet pressure (Pin) to the calculated inlet pressure (P(0)) by the computational fluid dynamic (CFD) simulation (open square, Pin; closed triangle, P(0)). The fluid is bovine blood with a viscosity of 0.0047 kg/m-s (4.7 cP). The error bars are standard deviation with N≥3.*N=1.
Grahic Jump Location
Predicted plasma-free hemoglobin released by a single cavitation event per ml of plasma (PFHbs) for cavitation bubbles of varying initial radius. The lysis criterion was 105 s−1. The pressure profile, P(τ), was taken from the computational fluid dynamics simulation with Vin=0.73 m/s and Po=−23 kPa (−170 mmHg).
Grahic Jump Location
Rate of plasma-free hemoglobin (PFHb) generation versus Cavitation Number (σ) for the recirculating flow experiment. Circuit flow rate was constant at 2.8 L/min with the free-stream pressure varied to vary σ. The blood was freshly collected from bovine. The error bars are standard deviation with N=3.
Grahic Jump Location
Rate of plasma-free hemoglobin (PFHb) generation versus Cavitation Number (σ) for the recirculating flow experiments (open square, freshly collected bovine blood; closed square, two-day-old bovine blood). Circuit flow rate was constant at 3 L/min with the free-stream pressure varied to vary σ and N=1.



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