RESEARCH PAPERS: Papers on Tissue Engineering

Semipermeable Polymer Tubes Provide a Microenvironment for In Vivo Analysis of Dorsal Root Regeneration

[+] Author and Article Information
J. H. Lustgarten, M. Proctor, R. I. Haroun, A. M. Avellino

Departments of Neurological Surgery at Columbia University College of Physicians & Surgeons, New York, NY

A. A. Pindzola

Department of Neuroscience, Case Western Reserve Medical School, Cleveland, OH

M. Kliot

The University of Washington, Seattle, WA 98195

J Biomech Eng 113(2), 184-188 (May 01, 1991) (5 pages) doi:10.1115/1.2891232 History: Received January 20, 1991; Revised February 01, 1991; Online March 17, 2008


The regeneration of lesioned axons is critically influenced by the local microenvironment. In this study, semipermeable polymer tubes were used to provide a defined microenvironment in vivo to analyze the regeneration of dorsal root axons under various conditions in the adult rat. Cut dorsal root fibers grew across a 2.7 mm gap within enclosed polymer tubes by 4 weeks. The pattern of axonal outgrowth was dramatically influenced by mechanical factors such as the inner surface topography of the polymer tube. Tubes containing various molecular and cellular substrates were also used to study their effect on dorsal root regeneration.

Copyright © 1991 by The American Society of Mechanical Engineers
Topics: Polymers , Fibers
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