The Recovery of Terminal Lymph Flow Following Occlusion

[+] Author and Article Information
G. E. Miller, J. L. Seale

Bioengineering Program, Texas A&M University, College Station, Texas 77843-3131

J Biomech Eng 109(1), 48-54 (Feb 01, 1987) (7 pages) doi:10.1115/1.3138641 History: Received January 10, 1986; Revised November 04, 1986; Online June 12, 2009


The effects of external pressure on the relative terminal lymphatic flow rate following occlusion of the lumph system were studied. Sulfur colloid tagged with 99m Tc was injected into the hind thigh of dogs prior to compressive loading. Initially, the lymphatic clearance of the tracer was measured for approximately forty minutes with no applied external pressure. The terminal lymph vessels were then occluded for thirty minutes with the application of an applied external pressure of 75 mm Hg. Finally, the lymphatic clearance following occlusion was measured with the application of a nonocclusive pressure. External pressures of 0, 30, and 45 mm Hg were tested to determine the effects of post-occlusive pressure application on terminal lymphatic clearance. Results indicated that terminal lymphatic clearance did not resume for an applied pressure of 45 mm Hg following occlusion. The relative lymphatic clearance rate at an external pressure of 30 mm Hg following occlusion was 54% of the clearance rate for a 0 mm Hg applied pressure prior to lymph occlusion. The results for a 0 mm Hg external pressure following occlusion indicated a 23 percent clearance rate compared to the pre-occlusive state. A two compartment model was utilized to determine the lymphatic clearance rate per unit tissue volume of subcutaneous tissue from the experimental data for each pressure phase.

Copyright © 1987 by ASME
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