Influence of Hypothermia and Circulatory Arrest on Cerebral Temperature Distributions

[+] Author and Article Information
R. W. Olsen, H. Nikaidoh, R. C. Eberhart

Biomedical Engineering Program and Department of Surgery, University of Texas Health Science Center at Dallas, Dallas, Tex. 75235

L. J. Hayes, E. H. Wissler

Biomedical Engineering Program, University of Texas, Austin, Tex. 78712

J Biomech Eng 107(4), 354-360 (Nov 01, 1985) (7 pages) doi:10.1115/1.3138569 History: Received October 03, 1984; Revised July 09, 1985; Online June 15, 2009


A finite element model of the bioheat transfer equation has been developed to simulate the temperature distribution in the head of a subhuman primate. Simulations were made of the induction of deep hypothermia and of subsequent hypothermic circulatory arrest (HCA). Simulations of the circulatory arrest phase were performed with different values of surface heat transfer coefficient and tissue metabolic heat generation. Numerical results were compared with experimental data for the same procedure. The simulations indicate the brain cools rapidly to a near isothermal condition in response to an infusion of cold arterial blood. However, extracerebral structures cool much more slowly. The bulk of heat gain by the brain during HCA is due to heat transfer from these warmer extra-cerebral tissues. These results suggest extended cooling by cardiopulmonary bypass (CPB) combined with surface cooling pads should reduce or even prevent the rise of brain temperatures during HCA.

Copyright © 1985 by ASME
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