Cyclic Loading on the Red Cell Membrane in a Shear Flow: A Possible Cause of Hemolysis

[+] Author and Article Information
H. Niimi, M. Sugihara

National Cardiovascular Center Research Institute, Suita, Osaka, Japan

J Biomech Eng 107(2), 91-95 (May 01, 1985) (5 pages) doi:10.1115/1.3138541 History: Received July 02, 1984; Revised September 20, 1984; Online June 15, 2009


The fluid force acting on single human red cells in a high shear flow was analyzed. A two-dimensional elliptical microcapsule as a model of the deformed red cells was adopted to numerically calculate the distributions of the shear forces on both sides of the cell membrane. It is theoretically shown that the cell membrane undergoes an unsteady cyclic loading under the rotational motion around the interior. The mechanism leading to blood cell trauma is examined by repeatedly loading the continuously moving cell membrane.

Copyright © 1985 by ASME
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