Arteriovenous Difference of the Blood Density in the Coronary Circulation

[+] Author and Article Information
T. Kenner, M. Moser

Department of Physiology, University of Graz, Graz, Austria

W. Mohl

2nd Department of Surgery, University of Vienna, Vienna, Austria

J Biomech Eng 107(1), 34-40 (Feb 01, 1985) (7 pages) doi:10.1115/1.3138517 History: Received September 15, 1983; Revised January 05, 1984; Online June 15, 2009


The mechanical oscillator technique permits determining blood density continuously with high accuracy. Using this technique arteriovenous density gradients were recorded in the coronary vascular bed of anesthetized dogs. It was found that the coronary sinus blood has a higher density than arterial blood due to the loss of filtered fluid in the microcirculation. The amount of fluid loss corresponds to the lymph flow in the myocardium. Increase of venous pressure leads to an increase of the density gradient. Intermittent coronary sinus occlusion (ICSO) surprisingly leads to a reduction of the density gradient. Injection of osmotically hypertensive fluids influences the arteriovenous gradient by shifting extravascular fluid into the blood. The method permits the determination of filtration coefficients and to estimate the tissue volume available for fluid exchange.

Copyright © 1985 by ASME
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