Regulation of Transmural Myocardial Blood Flow

[+] Author and Article Information
J. I. E. Hoffman, R. W. Baer, F. L. Hanley, L. M. Messina

Cardiovascular Research Institute and the Departments of Pediatrics and Physiology, University of California, San Francisco, Calif. 94143

J Biomech Eng 107(1), 2-9 (Feb 01, 1985) (8 pages) doi:10.1115/1.3138516 History: Received September 15, 1983; Revised January 30, 1984; Online June 15, 2009


A major problem in understanding how myocardial blood flow is regulated is the common occurrence of subendocardial ischemia in many diseases, with or without coronary arterial disease. Two commonly held explanatory hypotheses were that high systolic intramyocardial pressures prevented flow to deep but not superficial muscle, or that in diastole tissue pressures were highest subendocardially. Neither hypothesis is tenable today, and the likeliest hypothesis is that retrograde systolic flow from the deeper muscle produces a longer time constant for diastolic flow in deep than in superficial muscle.

Copyright © 1985 by ASME
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