Parameter Sensitivity Analysis and Improvement of a Two-Layer Arterial Wall Model

[+] Author and Article Information
W. W. von Maltzahn

Biomedical Engineering Program, The University of Texas at Arlington, Arlington, Tex. 76019

J Biomech Eng 105(4), 389-392 (Nov 01, 1983) (4 pages) doi:10.1115/1.3138437 History: Received September 15, 1982; Revised June 15, 1983; Online June 15, 2009


The nonlinear two-layer arterial wall model introduced by von Maltzahn, et al. [11] is subjected to a rigorous parameter sensitivity and range of validity analysis. The model is based on the assumption that in large muscular conduit arteries the two mechanically significant layers are media and adventitia. Using curve-fitting techniques, the media is determined to be isotropic and the adventitia to be anisotropic. As a result of the range of validity analysis, the polynomial relationship for the energy density function of the media is changed to an exponential relationship. This leads to new coefficients for the polynomial of the adventitia. All coefficients have specific mechanical meanings. The parameter sensitivity analysis demonstrates convincingly that all model parameters are significantly important.

Copyright © 1983 by ASME
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