Abnormalities in the Membrane Material Properties of Hereditary Spherocytes

[+] Author and Article Information
R. E. Waugh, P. L. La Celle

Department of Radiation Biology and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, N.Y. 14642

J Biomech Eng 102(3), 240-246 (Aug 01, 1980) (7 pages) doi:10.1115/1.3149580 History: Received January 15, 1980; Revised February 10, 1980; Online June 15, 2009


Mechanical measurements of intrinsic membrane material properties are used to characterize the defect in hereditary spherocyte membrane at a continuum level. The value of the surface elastic shear modulus is two-thirds as large as normal values, and the value of the yield shear resultant is one-third as large as normal values. The viscosity of the surface above the elastic-plastic transition appears normal. Under similar geometric conditions, the force required to fragment a hereditary spherocyte is about one-third as large as the force required to fragment a normal cell.

Copyright © 1980 by ASME
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