A novel mouse model of surgically induced aortic valve regurgitation (AR) has been developed which leads to altered hemodynamics in the descending thoracic and abdominal aorta, in turn leading to extensive atherosclerotic lesions in these otherwise lesion free areas [1]. Previous work has shown that maps of oscillatory shear index (OSI) and relative residence time (RRT) are consistent with the plaque distribution [2] and plaque severity in AR mice.

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