Parameter sensitivity for large-scale systems that include several components which interface in series is presented. Large-scale systems can be divided into components or sub-systems to avoid excessive calculations in determining their optimum design. Model Coordination Method of Decomposition (MCMD) is one of the most commonly used methods to solve large-scale engineering optimization problems. In the Model Coordination Method of Decomposition, the vector of coordinating variables can be partitioned into two sub-vectors for systems with several components interacting in series. The first sub-vector consists of those variables that are common among all or most of the elements. The other sub-vector consists of those variables that are common between only two components that are in series. This study focuses on a parameter sensitivity analysis for this special case using MCMD.