The paper presents modeling and Design of Experiments (DOE) analysis for a simple recuperated s-CO2 closed loop Brayton cycle operating at a maximum temperature of 600°C and a compressor inlet temperature of 45°C. The analysis highlights the impact of isentropic efficiencies of the turbine and compressor, decoupled in this case, on other equipment such as recuperator, gas cooler and heater, all of which have a bearing on the overall performance of the s-CO2 Brayton cycle. A MATLAB program coupled with REFPROP is used to perform the thermodynamic analysis of the cycle. A design space exploration with a Design of Experiments (DOE) study is undertaken using I-sight™ (multi-objective optimization software), which is coupled with the MATLAB code. The outcome of the DOE study provides the optimal pressure ratios and high side pressures for maximum cycle efficiency in the design space. By varying pressure ratios along with a floating high side pressure, the analysis reveals that the cycle performance exhibits a peak around a pressure ratio of 2.5, with cycle efficiency being the objective function. A further interesting outcome of the DOE study reveals that the isentropic efficiencies of the compressor and turbine have a strong influence not only on the overall cycle efficiency, but also the optimum pressure ratio as well as the threshold pressures (low as well as high side pressure). An important outcome of this exercise shows that the isentropic efficiency of the turbine has a much greater impact on the overall cycle performance as compared to that of the compressor.