Research Papers

The Effect of Oxidation on the Mechanical Response of Isolated Elastin and Aorta

[+] Author and Article Information
P. Mythravaruni

Department of Mechanical Engineering,
IIT Madras,
Chennai 600036, India
e-mail: varuni.mythra@gmail.com

Parag Ravindran

Department of Mechanical Engineering,
IIT Madras,
Chennai 600036, India
e-mail: paragr@iitm.ac.in

1Present address: Faculty of Civil and Environmental Engineering, Technion, Haifa 3200003, Israel

Manuscript received March 10, 2018; final manuscript received March 26, 2019; published online April 22, 2019. Assoc. Editor: Seungik Baek.

J Biomech Eng 141(6), 061002 (Apr 22, 2019) (9 pages) Paper No: BIO-18-1132; doi: 10.1115/1.4043355 History: Received March 10, 2018; Revised March 26, 2019

Oxidation of aorta by hydroxyl radicals produces structural changes in arterial proteins like elastin and collagen. This in turn results in change in the mechanical response of aorta. In this paper, a thermodynamically consistent constitutive model is developed within the framework of mixture theory, to describe the changes in aorta and isolated elastin with oxidation. The model is then studied under uniaxial extension using experimental data from literature.

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Grahic Jump Location
Fig. 1

Configurations associated with deforming viscoelastic body

Grahic Jump Location
Fig. 2

Evolution of protein carbonyl in the oxidized elastin and oxidized aorta. It is noted that the experimental data for oxidized elastin are limited.

Grahic Jump Location
Fig. 3

Stress versus stretch of aorta samples after oxidation treatment for time periods of 0 h, 2 h, 8 h, and 24 h

Grahic Jump Location
Fig. 4

Stress versus stretch of isolated elastin samples after oxidation treatment for time periods of 0 h, 2 h, and 4 h



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