0
research-article

On Stability of Specific Adhesion of Particles to Membranes in Simple Shear Flow

[+] Author and Article Information
Mohammad Hossein Moshaei

Department of Mechanical Engineering, Ohio University, Athens OH 45701, USA
mm733315@ohio.edu

Mohammad Tehrani

Department of Mechanical Engineering, Ohio University, Athens OH 45701, USA
mj908614@ohio.edu

Alireza Sarvestani

Department of Mechanical Engineering, Ohio University, Athens OH 45701, USA; Department of Mechanical Engineering, Mercer University, Macon GA 31207, USA
sarvesta@ohio.edu

1Corresponding author.

ASME doi:10.1115/1.4041046 History: Received November 23, 2017; Revised July 25, 2018

Abstract

Adhesion of carrier particles to the luminal surface of endothelium under hemodynamic flow conditions is critical for successful vascular drug delivery. Endothelial cells line the inner surface of blood vessels. The effect of mechanical behavior of this compliant surface on the adhesion of blood-borne particles is unknown. In this contribution, we use a phase-plane method, first developed by Hammer and Lauffenburger [Biophysical Journal, 52, 475 (1987)], to analyze the stability of specific adhesion of a spherical particle to a compliant interface layer. We construct a phase diagram that predicts the state of particle adhesion, subjected to an incident simple shear flow, in terms of interfacial elasticity, shear rate, binding affinity of cell adhesive molecules, and their surface density. The main conclusion is that the local deformation of the flexible interface inhibits the stable adhesion of the particle. In comparison with adhesion to a rigid substrate, a greater ligand density is required to establish a stable adhesion between a particle and a compliant interface. The results can be used for the rational design of particles in vascular drug delivery.

Copyright (c) 2018 by ASME
Your Session has timed out. Please sign back in to continue.

References

Figures

Tables

Errata

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In