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research-article

Comparison of Heat Transfer Enhancement between Magnetic and Gold Nano-Particles during HIFU Sonication

[+] Author and Article Information
Surendra Devarakonda

Department of Mechanical, Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH 45221
devarasb@mail.uc.edu

Matthew R. Myers

Division of Applied Mechanics, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993
matthew.myers@fda.hhs.gov

Rupak K. Banerjee

Department of Mechanical, Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH 45221
rupak.banerjee@uc.edu

1Corresponding author.

ASME doi:10.1115/1.4040120 History: Received December 10, 2017; Revised April 22, 2018

Abstract

Long procedure times and collateral damage remain challenges in high-intensity focused ultrasound (HIFU) medical procedures. Magnetic nanoparticles (mNPs) and gold nanoparticles (gNPs) have the potential to reduce the acoustic intensity and/or exposure time required in these procedures. In this research, we investigated relative advantages of using gNPs and mNPs during HIFU thermal-ablation procedures. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0.0625%, and 0.125%) of gNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 sec. It was observed that when the concentration of gNPs was doubled from 0.0625% to 0.125%, the temperature rise increased by 80% for a power of 5.2 W. For a fixed concentration (0.0625%), the energy absorption was 1.7 times greater for mNPs than gNPs for a power of 5.2 W. Also, for the power of 14.5 W, the sonication time required to generate a lesion volume of 50 mm3 decreased by 1.4 times using mNPs, compared with gNPs, at a concentration of 0.0625%. We conclude that mNP's are more likely than gNP's to produce a thermal enhancement in HIFU ablation procedures.

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