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research-article

An FSI Modeling Approach to Combine IVUS and OCT for More Accurate Patient-Specific Coronary Cap Thickness and Stress/Strain Calculations

[+] Author and Article Information
Xiaoya Guo

Department of Mathematics, Southeast University, Nanjing, 210096, China
guoxiaoya1990@163.com

Don P. Giddens

Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30307, USA; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332 USA
don.giddens@bme.gatech.edu

David Molony

Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30307, USA
dmolony@emory.edu

Chun Yang

Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609 USA
chyang0@126.com

Habib Samady

Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30307, USA
hsamady@emory.edu

Jie Zheng

Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, 63110, USA
zhengj@wustl.edu

Gary Mintz

The Cardiovascular Research Foundation, Columbia University, New York, NY 10022, USA
gsm18439@aol.com

Akiko Maehara

The Cardiovascular Research Foundation, Columbia University, New York, NY 10022, USA
amaehara@crf.org

Liang Wang

Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609 USA
lwang6@WPI.EDU

Xuan Pei

School of Biological Science & Medical Engineering, Southeast University, Nanjing, China
flyskyxuan@126.com

Zhi-Yong Li

School of Biological Science & Medical Engineering, Southeast University, Nanjing, China
zylicam@gmail.com

Dalin Tang

Department of Mathematics, Southeast University, Nanjing, 210096, China; Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609 USA
dtang@wpi.edu

1Corresponding author.

ASME doi:10.1115/1.4038263 History: Received May 28, 2017; Revised October 04, 2017

Abstract

Accurate cap thickness and stress/strain quantifications are of fundamental importance for vulnerable plaque research. Virtual histology intravascular ultrasound (VH-IVUS) sets cap thickness to zero when cap is under resolution limit and IVUS does not see it. An innovative modeling approach combining IVUS and optical coherence tomography (OCT) is introduced for cap thickness quantification and more accurate cap stress/strain calculations. In vivo IVUS and OCT coronary plaque data were acquired with informed consent obtained. IVUS and OCT images were merged to form the IVUS+OCT data set, with biplane angiography providing 3D vessel curvature. For components where VH-IVUS set zero cap thickness (i.e., no cap), a cap was added with minimum cap thickness set as 50 and 180 micron to generate IVUS50 and IVUS180 data sets for model construction, respectively. 3D FSI models based on IVUS+OCT, IVUS50 and IVUS180 data sets were constructed to investigate cap thickness impact on stress/strain calculations. Compared to IVUS+OCT, IVUS50 underestimated mean cap thickness (27 slices) by 34.5%, overestimated mean cap stress by 45.8%, (96.4 vs. 66.1 kPa). IVUS50 maximum cap stress was 59.2% higher than that from IVUS+OCT model (564.2 vs. 354.5 kPa). Differences between IVUS and IVUS+OCT models for cap strain and flow shear stress were modest (cap strain <12%; FSS <6%). IVUS+OCT data and models could provide more accurate cap thickness and stress/strain calculations which will serve as basis for further plaque investigations.

Copyright (c) 2017 by ASME; use license CC-BY 4.0
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