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Technical Brief

Stiffness Properties of Adventitia, Media and Full Thickness Human Atherosclerotic Carotid Arteries in the Axial and Circumferential Directions

[+] Author and Article Information
Allen H. Hoffman

Mechanical Engineering Department, Worcester Polytechnic Institute, Worcester, MA 01609
ahoffman@WPI.EDU

Zhongzhao Teng

Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609; Department of Radiology, University of Cambridge, Cambridge, United Kingdom
zt215@cam.ac.uk

Jie Zheng

Mallinckrodt Inst. of Radiology, Washington University in St. Louis, MO 63110
zhengj@wustl.edu

Zheyang Wu

Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609
zheyangwu@WPI.EDU

Pamela Woodard

Mallinckrodt Inst. of Radiology, Washington University in St. Louis, MO 63110
woodardp@wustl.edu

Kristen Billiar

Biomedical Engineering Department, Worcester Polytechnic Institute, Worcester, MA 01609
kbilliar@wpi.edu

Liang Wang

School of Biological Science & Medical Engineering, Southeast University, Nanjing, 210096, China
lwang6@WPI.EDU

Dalin Tang

Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609; School of Biological Science & Medical Engineering, Southeast University, Nanjing, 210096, China
dtang@wpi.edu

1Corresponding author.

ASME doi:10.1115/1.4037794 History: Received April 19, 2017; Revised August 13, 2017

Abstract

Introduction. Arteries can be considered as layered composite material. Experimental data on the stiffness of human atherosclerotic carotid arteries and their media and adventitia layers is very limited. This study used uniaxial tests to determine the stiffness (tangent modulus) of human carotid artery sections containing AHA type II and III lesions. Methods. Axial and circumferential oriented adventitia, media and full thickness specimens were prepared from 6 human carotid arteries (total tissue strips: 71). Each artery yielded 12 specimens with 2 specimens in each of the following 6 categories; axial full thickness, axial adventitia, axial media, circumferential full thickness, circumferential adventitia and circumferential media. Uniaxial testing was performed using Inspec 2200 controlled by software developed using LabVIEW. Results. The mean stiffness of the adventitia was 3,570±667 and 2,960±331 kPa in the axial and circumferential directions respectively, while the corresponding values for the media were 1,070±186 and 1,800±384 kPa. The adventitia was significantly stiffer than the media in both the axial (p=0.003) and circumferential (p=0.010) directions. The stiffness of the full thickness specimens was nearly identical in the axial (1,540±186) and circumferential (1,530±389 kPa) directions. The differences in axial and circumferential stiffness of media and adventitia were not statistically significant.

Copyright (c) 2017 by ASME
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