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research-article

An enhanced spring-particle model for red blood cell structrual mechanics

[+] Author and Article Information
Mingzhu Chen

School of Mechanical & Design Engineering, Dublin Institute of Technology, Bolton Street, Dublin 1, Ireland
mingzu.chen@dit.ie

Fergal Boyle

School of Mechanical & Design Engineering, Dublin Institute of Technology, Bolton Street, Dublin 1, Ireland
fergal.boyle@dit.ie

1Corresponding author.

ASME doi:10.1115/1.4037590 History: Received May 30, 2017; Revised July 13, 2017

Abstract

Red blood cells (RBCs) are the most abundant cellular element suspended in blood. Together with the usual biconcave-shaped RBCs, i.e. discocytes, unusual-shaped RBCs are also observed under physiological and experimental conditions, e.g. stomatocytes and echinocytes. Stomatocytes and echinocytes are formed from discocytes and in addition can revert back to being discocytes; this shape change is known as the stomatocyte-discocyte-echinocyte (SDE) transformation. To-date limited research has been conducted on the numerical prediction of the full SDE transformation. Spring-particle RBC (SP-RBC) models are commonly used to numerically predict RBC mechanics and rheology. However, these models are incapable of predicting the full SDE transformation because the typically-employed bending model always leads to numerical instability with severely deformed shapes. In this work an enhanced SP-RBC model is proposed in order to extend the capability of this model type and so that the full SDE transformation can be reproduced. This is achieved through the leveraging of an advanced bending model. Transformed vesicle and RBC shapes are predicted for a range of reduced volume and MAD, and very good agreement is obtained in the comparison of predicted shapes with experimental observations. Vesicle and SDE transformation phase diagrams are developed and, importantly, in the SDE case shape boundaries are proposed for the first time.

Copyright (c) 2017 by ASME
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