0
research-article

Non-uniform Moving Boundary Method for CFD Simulation of Intrathecal Cerebrospinal Flow Distribution in a Cynomolgus Monkey

[+] Author and Article Information
Mohammadreza Khani

Neurophysiological Imaging and Modeling Laboratory, Department of Biological Engineering, University of Idaho, Moscow, ID
khan0242@vandals.uidaho.edu

Tao Xing

Department of Mechanical Engineering, University of Idaho, Moscow, ID, USA
xing@uidaho.edu

Christina Gibbs

Neurophysiological Imaging and Modeling Laboratory, Department of Biological Engineering, University of Idaho, Moscow, ID, USA
gibb6751@vandals.uidaho.edu

John Oshinski

Department of Radiology, Emory University, Atlanta, GA, USA
jnoshin@emory.edu

Gregory R. Stewart

Alchemy Neuroscience, Hanover, MA, GERMANY
grstewart77@gmail.com

Jillynne R. Zeller

Northern Biomedical Research, Spring Lake, MI, USA
Jill.Zeller@northernbiomedical.com

Bryn A. Martin

Neurophysiological Imaging and Modeling Laboratory, Department of Biological Engineering, University of Idaho, Moscow, ID, USA
brynm@uidaho.edu

1Corresponding author.

ASME doi:10.1115/1.4036608 History: Received January 12, 2017; Revised April 24, 2017

Abstract

A detailed quantification and understanding of cerebrospinal fluid (CSF) dynamics may improve detection and treatment of central nervous system (CNS) diseases and help optimize CSF system-based delivery of CNS therapeutics. This study presents a computational fluid dynamics (CFD) model that utilizes a non-uniform moving boundary approach to accurately reproduce the non-uniform distribution of CSF flow along the spinal subarachnoid space (SAS) of a single cynomolgus monkey. A magnetic resonance imaging (MRI) protocol was developed and applied to quantify subject-specific CSF space geometry and flow and define the CFD domain and boundary conditions. An algorithm was implemented to reproduce the axial distribution of unsteady CSF flow by non-uniform deformation of the dura surface. Results showed that maximum difference between the MRI measurements and CFD simulation of CSF flow rates was <3.6%. CSF flow along the entire spine was laminar with a peak Reynold's number of ~150 and average Womersley number of ~5.4. Maximum CSF flow rate was present at the C4-C5 vertebral level. Deformation of the dura ranged up to a maximum of 134 ┬Ám. Geometric analysis indicated that total spinal CSF space volume was ~8.7 ml. Average hydraulic diameter, wetted perimeter and SAS area was 2.9 mm, 37.3 mm and 27.24 mm2, respectively. CSF pulse wave velocity along the spine was quantified to be 1.2 m/s.

Copyright (c) 2017 by ASME
Your Session has timed out. Please sign back in to continue.

References

Figures

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In