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research-article

Empirically Determined Vascular Smooth Muscle Cell Mechano-Adaptation Law

[+] Author and Article Information
Kerianne E. Steucke

Department of Biomedical Engineering, University of Minnesota – Twin Cities 312 Church St. SE NHH 7-105, Minneapolis, MN 55455
steu0057@umn.edu

Zaw Win

Department of Biomedical Engineering, University of Minnesota – Twin Cities 312 Church St. SE NHH 7-105, Minneapolis, MN 55455
winxx005@umn.edu

Taylor R. Stemler

Department of Biomedical Engineering, University of Minnesota – Twin Cities 312 Church St. SE NHH 7-105, Minneapolis, MN 55455
steml002@umn.edu

Emily E. Walsh

Department of Biomedical Engineering, University of Minnesota – Twin Cities 312 Church St. SE NHH 7-105, Minneapolis, MN 55455
walsh553@umn.edu

Jennifer L. Hall

Department of Medicine, Division of Cardiology, University of Minnesota – Twin Cities 2231 6th St. SE CCRB, Minneapolis, MN 55455
jlhall@umn.edu

Patrick W. Alford

Department of Biomedical Engineering, University of Minnesota – Twin Cities 312 Church St. SE NHH 7-105, Minneapolis, MN 55455
pwalford@umn.edu

1Corresponding author.

ASME doi:10.1115/1.4036454 History: Received December 01, 2016; Revised March 20, 2017

Abstract

Cardiovascular disease can alter the mechanical environment of the vascular system, leading to mechano-adaptive growth and remodeling. Predictive models of arterial mechano-adaptation could improve patient treatments and outcomes in cardiovascular disease. Vessel-scale mechano-adaptation includes remodeling of both the cells and extracellular matrix. Here, we aimed to experimentally measure and characterize a phenomenological mechano-adaptation law for vascular smooth muscle cells (VSMCs) within an artery. To do this, we developed a highly controlled and reproducible system for applying a chronic step-change in strain to individual VSMCs with in vivo like architecture, and tracked the temporal cellular stress evolution. We found that a simple linear growth law was able to capture the dynamic stress evolution of VSMCs in response to this mechanical perturbation. These results provide an initial framework for development of clinically relevant models of vascular remodeling that include VSMC adaptation.

Copyright (c) 2017 by ASME
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