0
research-article

The effect of trabeculae carneae on left ventricular diastolic compliance: improvement in compliance with trabecular cutting

[+] Author and Article Information
David L. Halaney

Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX
dhalaney@engr.ucr.edu

Arnav Sanyal

Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249
arnavsanyal@gmail.com

Navid A. Nafissi

Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229
david.halaney@hotmail.com

Daniel Escobedo

Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX
ESCOBEDOD@uthscsa.edu

Martin Goros

Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229
Goros@uthscsa.edu

Joel Michalek

Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229
michalekj@uthscsa.edu

Pedro J. Acevedo

Department of Anatomy, University of Environmental and Applied Sciences U.D.C.A., Bogotá, Colombia
pacevedo@udca.edu.co

William Pérez

Department of Anatomy, Faculty of Veterinary Medicine, University of the Republic, Montevideo, Uruguay
vetanat@gmail.com

G. Patricia Escobar

Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229
escobarg@uthscsa.edu

Marc D. Feldman

Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX
feldmanm@uthscsa.edu

Hai-Chao Han

Department of Mechanical Engineering, University of Texas at San Antonio, San Antonio, TX 78249
hchan@utsa.edu

1Corresponding author.

ASME doi:10.1115/1.4035585 History: Received May 25, 2016; Revised December 13, 2016

Abstract

The role of trabeculae carneae in modulating left ventricular (LV) diastolic compliance remains unclear. The objective of this study was to determine the contribution of trabeculae carneae to the LV diastolic compliance. LV pressure-volume compliance curves were measured in six human heart explants from patients with LV hypertrophy at baseline and following trabecular cutting. The effect of trabecular cutting was also analyzed with finite element model simulations. Our results demonstrated that LV compliance improved after trabecular cutting (p<0.001). Finite element simulations further demonstrated that stiffer trabeculae reduce LV compliance further, and that the presence of trabeculae reduced the wall stress in the apex. In conclusion, we demonstrate that integrity of the LV and trabeculae is important to maintain LV stiffness and loss in trabeculae leads to more LV compliance.

Copyright (c) 2016 by ASME
Your Session has timed out. Please sign back in to continue.

References

Figures

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In