The availability of diverse mouse models is revealing increasingly greater information on arterial mechanics, including homeostatic adaptations and pathologic maladaptations to genetic, pharmacological, and surgical manipulations. Fundamental to understanding such biomechanical changes, however, is reliable information on appropriate control vessels. In this paper, we contrast 15 different geometrical and mechanical metrics of biaxial ascending aortic mechanics across 7 different types of possible control mice. We show that there is a comforting similarity across these multiple controls for most, though not all, metrics. In particular, three potential controls, namely non-induced conditional mice, exhibit higher values of distensibility, an important clinical metric of structural stiffness, and two potential controls exhibit higher values of intrinsic circumferential material stiffness. There is motivation, therefore, to understand better the potential changes that arise with non-induced Cre-lox or similar approaches for generating mutations conditionally. In cases of germline mutations generated by breeding heterozygous +/- mice, however, the resulting homozygous +/+ mice appear to exhibit properties similar to traditional (C57BL/6) controls.