The fixation of uncemented acetabular components largely depends on the amount of bone ingrowth, which is influenced by the design of the implant surface texture. The objective of this numerical study is to evaluate the effect of these implant texture design factors on bone ingrowth around an acetabular component. The novelty of this study lies in comparative Finite Element analysis of 3D microscale models of the implant-bone interface, considering patient-specific mechanical environment, host bone material property and implant-bone relative displacement, in combination with sequential mechanoregulatory algorithm and design of experiment based statistical framework. Results indicated that the bone ingrowth process was inhibited due to an increase in inter-bead spacing from 200µm to 600µm and bead diameter from 1000µm to 1500µm and a reduction in bead height from 900µm to 600µm. Bead height, a main effect, was found to have a predominant influence on bone ingrowth. Amongst the interaction effects, the combination of bead height and bead diameter was found to have a pronounced influence on bone ingrowth process. A combination of low inter-bead spacing (P = 200µm), low bead diameter (D = 1000µm) and high bead height (H = 900µm) facilitated peri-acetabular bone ingrowth and an increase in average Young's modulus of newly formed tissue layer. Hence, such a surface texture design seemed to provide improved fixation of the acetabular component.