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Technical Brief

Repeated Loading Behavior of Pediatric Porcine Common Carotid Arteries

[+] Author and Article Information
Stephanie A. Pasquesi, Yishan Liu

Department of Bioengineering,
University of Pennsylvania,
240 Skirkanich Hall,
210 South 33rd Street,
Philadelphia, PA 19104-6321

Susan S. Margulies

Department of Bioengineering,
University of Pennsylvania,
240 Skirkanich Hall,
210 South 33rd Street,
Philadelphia, PA 19104-6321
e-mail: margulie@seas.upenn.edu

1Corresponding author.

Manuscript received January 4, 2016; final manuscript received June 5, 2016; published online November 3, 2016. Assoc. Editor: Barclay Morrison.

J Biomech Eng 138(12), 124502 (Nov 03, 2016) (5 pages) Paper No: BIO-16-1005; doi: 10.1115/1.4033883 History: Received January 04, 2016; Revised June 05, 2016

Rapid flexion and extension of the neck may occur during scenarios associated with traumatic brain injury (TBI), and understanding the mechanical response of the common carotid artery (CCA) to longitudinal stretch may enhance understanding of contributing factors that may influence CCA vasospasm and exacerbate ischemic injury associated with TBI. Immature (4-week-old) porcine CCAs were tested under subcatastrophic (1.5 peak stretch ratio) cyclic loading at 3 Hz for 30 s. Under subcatastrophic cyclic longitudinal extension, the immature porcine CCA displays softening behavior. This softening can be represented by decreasing peak stress and increasing corner stretch values with an increasing number of loading cycles. This investigation is an important first step in the exploration of fatiguelike behavior in arterial tissue that may be subjected to repeated longitudinal loads.

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Figures

Grahic Jump Location
Fig. 1

Vessel testing device including (A) lab jack, (B) load cell, (C) saline inlet, (D) pressure sensors, (E) 14G blunt-tipped needle grips, (F) gear–chain system, (G) rotary motor, (H) threaded shafts, (I) translating plate, and (J) laser displacement sensor

Grahic Jump Location
Fig. 2

Representative plot of cyclic stress versus stretch ratio and a single cycle loading portion (inset) defining the toe and linear regions. Peak stress decreases and corner stretch increases with successive cycles. A large amount of hysteresis is observed in the first cycle compared with subsequent cycles.

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