0
Journal of Biomechanical Engineering | Volume 137 | Issue 8 | research-article
Research Papers

Evaluating the Effect of Sinex® (0.05% Oxymetazoline) Nasal Spray on Reduction of Nasal Congestion Using Computational Fluid Dynamics

[+] Author and Article Information
Aravind Kishore

UC Simulation Center,
Department of Mechanical and
Materials Engineering,
University of Cincinnati,
PO Box 210072,
Cincinnati, OH 45221
e-mail: kishora@email.uc.edu

Lauren Blake

UC Simulation Center,
Department of Mechanical and
Materials Engineering,
University of Cincinnati,
PO Box 210072,
Cincinnati, OH 45221
e-mail: blakeln@mail.uc.edu

Chengming Wang

Procter & Gamble Company (P&G),
8700 Mason-Montgomery Road,
Mason, OH 45040
e-mail: wang.c.4@pg.com

Shan Ba

Procter & Gamble Company (P&G),
8700 Mason-Montgomery Road,
Mason, OH 45040
e-mail: ba.s@pg.com

Gary Gross

Procter & Gamble Company (P&G),
8611 Beckett Road,
E142,
West Chester, OH 45069
e-mail: gross.gj@pg.com

1Corresponding author.

Manuscript received November 12, 2014; final manuscript received March 6, 2015; published online June 23, 2015. Assoc. Editor: Naomi Chesler.

J Biomech Eng 137(8), 081011 (Aug 01, 2015) (9 pages) Paper No: BIO-14-1625; doi: 10.1115/1.4030825 History: Received November 12, 2014; Revised March 06, 2015; Online June 23, 2015
Article
References
Figures
Tables

Computational fluid dynamics (CFD) was used to simulate air flow changes in reconstructed nasal passages based on magnetic resonance imaging (MRI) data from a previous clinical study of 0.05% Oxymetazoline (Vicks Sinex Micromist®). Total-pressure boundary conditions were uniquely applied to accommodate low patency subjects. Net nasal resistance, the primary simulation outcome, was determined using a parallel-circuit analogy and compared across treatments. Relative risk (RR) calculations show that for a 50% reduction in nasal resistance, subjects treated with Sinex® are 9.1 times more likely to achieve this after 8 hr, and 3.2 times more likely after 12 hr compared to Sham.
FIGURES IN THIS ARTICLE
<>
Copyright © 2015 by ASME
Your Session has timed out. Please sign back in to continue.

References

1
Baraniuk, J. N., 2011, “Subjective Nasal Fullness and Objective Congestion,” Proc. Am. Thorac. Soc., 8(1), pp. 62–69. [CrossRef] [PubMed]
2
Craig, T. J., Teets, S., Lehman, E. B., Chinchilli, V. M., and Zwillich, C., 1998, “Nasal Congestion Secondary to Allergic Rhinitis as a Cause of Sleep Disturbance and Daytime Fatigue and the Response to Topical Nasal Corticosteroids,” J. Allergy Clin. Immunol., 101(5), pp. 633–637. [CrossRef] [PubMed]
3
Peskin, C. S., 1977, “Numerical Analysis of Blood Flow in the Heart,” J. Comput. Phys., 25(3), pp. 220–252. [CrossRef]
4
Marshall, I., Zhao, S., Papathanasopoulou, P., Hoskins, P., and Xu, X. Y., 2004, “MRI and CFD Studies of Pulsatile Flow in Healthy and Stenosed Carotid Bifurcation Models,” J. Biomech., 37(5), pp. 679–687. [CrossRef] [PubMed]
5
Kimbell, J. S., Segal, R. A., Asgharian, B., Wong, B. A., Schroeter, J. D., Southall, J. P., Dickens, C. J., Brace, G., and Miller, F. J., 2007, “Characterization of Deposition From Nasal Spray Devices Using a Computational Fluid Dynamics Model of the Human Nasal Passages,” J. Aerosol Med., 20(1), pp. 59–74. [CrossRef] [PubMed]
6
Inthavong, K., Tian, Z. F., Tu, J. Y., Yang, W., and Xue, C., 2008, “Optimising Nasal Spray Parameters for Efficient Drug Delivery Using Computational Fluid Dynamics,” Comput. Biol. Med., 38(6), pp. 713–726. [CrossRef] [PubMed]
7
Mihaescu, M., Mylavarapu, G., Gutmark, E. J., and Powell, N. B., 2011, “Large Eddy Simulation of the Pharyngeal Airflow Associated With Obstructive Sleep Apnea Syndrome at Pre and Post-Surgical Treatment,” J. Biomech., 44(12), pp. 2221–2228. [CrossRef] [PubMed]
8
Rhee, J. S., Pawar, S. S., Garcia, G. J. M., and Kimbell, J. S., 2014, “Toward Personalized Nasal Surgery Using Computational Fluid Dynamics,” Arch. Facial Plast. Surg., 13(5), pp. 305–310. [CrossRef]
9
Pritchard, S., Glover, M., Guthrie, G., Brum, J., Ramsey, D., Kappler, G., Thomas, P., Stuart, S., Hull, D., and Gowland, P., 2013, “Effectiveness of 0.05% Oxymetazoline (Vicks Sinex Micromist®) Nasal Spray in the Treatment of Objective Nasal Congestion Demonstrated to 12 h Post-Administration by Magnetic Resonance Imaging,” Pulm. Pharmacol. Ther., 27(1), pp. 121–126. [CrossRef] [PubMed]
10
O'Dell, W., 2003, “DICOM Rewriter (Anonymizer),” http://rsb.info.nih.gov/ij/plugins/dicom-rewriter.html
11
Mylavarapu, G., Murugappan, S., Mihaescu, M., Kalra, M., Khosla, S., and Gutmark, E., 2009, “Validation of Computational Fluid Dynamics Methodology Used for Human Upper Airway Flow Simulations,” J. Biomech., 42(10), pp. 1553–1559. [CrossRef] [PubMed]
12
Kim, S. K., Na, Y., Kim, J. I., and Chung, S. K., 2013, “Patient Specific CFD Models of Nasal Airflow: Overview of Methods and Challenges,” J. Biomech., 46(2), pp. 299–306. [CrossRef] [PubMed]
13
Keyhani, K., Scherer, P. W., and Mozell, M. M., 1995, “Numerical Simulation of Airflow in the Human Nasal Cavity,” ASME J. Biomech. Eng., 117(4), pp. 429–441. [CrossRef]
14
Wexler, D., Segal, R., and Kimbell, J., 2005, “Aerodynamic Effects of Inferior Turbinate Reduction: Computational Fluid Dynamics Simulation,” Arch. Otolaryngol. Head. Neck Surg., 131(12), pp. 1102–1107. [CrossRef] [PubMed]
15
Martini, F., Ober, W., Garrison, C., Welch, K., and Hutchings, R., 2001, Fundamentals of Anatomy & Physiology, 5th ed., Prentice Hall, Upper Saddle River, NJ.
16
Davis, S. S., and Eccles, R., 2004, “Nasal Congestion: Mechanisms, Measurement and Medications. Core Information for the Clinician,” Clin. Otolaryngol. Allied Sci., 29(6), pp. 659–666. [CrossRef] [PubMed]
17
Connell, J. T., 1982, “Rhinometry: Measurement of Nasal Patency,” Ann. Allergy, 49(4), pp. 179–185. [PubMed]
18
Hamilton, L., 1979, “Nasal Airway Resistance: Its Measurement and Regulation,” Physiologist, 22(3), pp. 43–49. [PubMed]
19
Atsumi, T., Takada, S., Binti Ali, E., Jinno, M., and Lida, M., 2014, “Evaluation of Nasal Airflow and Resistance by Numerical Modeling,” 7th World Congress of Biomechanics, p. M131.
20
Connell, J. T., and Linzmayer, M. I., 1987, “Comparison of Nasal Airway Patency Changes After Treatment With Oxymetazoline and Pseudoephedrine,” Am. J. Rhinol., 1(2), pp. 87–94. [CrossRef]
21
Eccles, R., 1978, “The Central Rhythm of the Nasal Cycle,” Acta Otolaryngol., 86(5–6), pp. 464–468. [CrossRef] [PubMed]
22
Zubair, M., Shuaib, I. L., Abdullah, M. Z., and Hamid, S. A., 2011, “Review: A Critical Overview of Limitations of CFD Modeling in Nasal Airflow,” J. Med. Biol. Eng., 32(2), pp. 77–84. [CrossRef]
23
Subramaniam, R. P., Richardson, R. B., Morgan, K. T., Kimbell, J. S., and Guilmette, R. A., 1998, “Computational Fluid Dynamics Simulations of Inspiratory Airflow in the Human Nose and Nasopharynx,” Inhal. Toxicol., 10(2), pp. 91–120. [CrossRef]
24
Garcia, G. J. M., Bailie, N., Martins, A., and Kimbell, J. S., 2007, “Atrophic Rhinitis: A CFD Study of Air Conditioning in the Nasal Cavity,” J. Appl. Physiol., 103(3), pp. 1082–1092. [CrossRef] [PubMed]

Figures

Grahic Jump Location
Fig. 2

Calculation of nasal resistance; steeper slopes indicate higher nasal resistance

+Calculation of nasal resistance; steeper slopes indicate higher nasal resistance
View Large  |  Save Figure  |  Download Slide (.ppt)
Calculation of nasal resistance; steeper slopes indicate higher nasal resistance
Grahic Jump Location
Fig. 1

Nasal passages (darker gray region) reconstructed from MRI slices using Simpleware. Face included for illustrative purposes only.

+Nasal passages (darker gray region) reconstructed from MRI slices using Simpleware. Face included for illustrative purposes only.
View Large  |  Save Figure  |  Download Slide (.ppt)
Nasal passages (darker gray region) reconstructed from MRI slices using Simpleware. Face included for illustrative purposes only.
Grahic Jump Location
Fig. 6

Scatter plots for percentage reduction of nasal resistance: (a) after 8 hr; (b) after 12 hr

+Scatter plots for percentage reduction of nasal resistance: (a) after 8 hr; (b) after 12 hr
View Large  |  Save Figure  |  Download Slide (.ppt)
Scatter plots for percentage reduction of nasal resistance: (a) after 8 hr; (b) after 12 hr
Grahic Jump Location
Fig. 7

Chart of Relative Risk (RR) reductions of 50% or more at both time points

+Chart of Relative Risk (RR) reductions of 50% or more at both time points
View Large  |  Save Figure  |  Download Slide (.ppt)
Chart of Relative Risk (RR) reductions of 50% or more at both time points
Grahic Jump Location
Fig. 3

3D CAD models reconstructed from MRI slices of subject NN (Sinex®) at the three time points qualitatively show an increase in flow volume after treatment

+3D CAD models reconstructed from MRI slices of subject NN (Sinex®) at the three time points qualitatively show an increase in flow volume after treatment
View Large  |  Save Figure  |  Download Slide (.ppt)
3D CAD models reconstructed from MRI slices of subject NN (Sinex®) at the three time points qualitatively show an increase in flow volume after treatment
Grahic Jump Location
Fig. 4

Flow path lines in nasal passages of subject NN (Sinex®) at three time points: (a) predose, (b) 8 hr post-treatment, and (c) 12 hr post-treatment. Dashed box showing location of nasal valve in predose image.

+Flow path lines in nasal passages of subject NN (Sinex®) at three time points: (a) predose, (b) 8 hr post-treatment, and (c) 12 hr post-treatment. Dashed box showing location of nasal valve in predose image.
View Large  |  Save Figure  |  Download Slide (.ppt)
Flow path lines in nasal passages of subject NN (Sinex®) at three time points: (a) predose, (b) 8 hr post-treatment, and (c) 12 hr post-treatment. Dashed box showing location of nasal valve in predose image.
Grahic Jump Location
Fig. 5

Nasal passage anatomy (coronal view) SM: superior meatus; MM: medial meatus; IM: inferior meatus

+Nasal passage anatomy (coronal view) SM: superior meatus; MM: medial meatus; IM: inferior meatus
View Large  |  Save Figure  |  Download Slide (.ppt)
Nasal passage anatomy (coronal view) SM: superior meatus; MM: medial meatus; IM: inferior meatus

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Antilock-Braking System Using Fuzzy Logic
International Conference on Mechanical and Electrical Technology, 3rd, (ICMET-China 2011), Volumes 1–3
Research of Key Technologies of the Stage Hydraulic System's Electro-Hydraulic Monitoring
International Conference on Information Technology and Management Engineering (ITME 2011)
Case Studies
Nonlinear Regression Modeling for Engineering Applications: Modeling, Model Validation, and Enabling Design of Experiments
List of Commercial Codes
Introduction to Finite Element, Boundary Element, and Meshless Methods
Development of Simulatiom of Pedestrian Uncontrolled Crossing Behavior
International Conference on Computer Technology and Development, 3rd (ICCTD 2011)
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
Sign In