Physiological loads that act on the femoropopliteal artery, in combination with stenting, can lead to uncharacteristic deformations of the stented vessel. The overall goal of this study was to investigate the effect of stent length and stent location on the deformation characteristics of the superficial femoral artery (SFA) using an anatomically accurate, three-dimensional finite element model of the leg. For a range of different stent lengths and locations, the deformation characteristics (length change, curvature change, and axial twist) that result from physiological loading of the SFA along with the mechanical behavior of the vessel tissue are investigated. Results showed that stenting portions of the SFA leads to a change in global deformation characteristics of the vessel. Increased stress and strain values and altered deformation characteristics were observed in the various stented cases of this study, which are compared to previous results of an unstented vessel. The study concludes that shortening, twist and curvature characteristics of the stented vessel are dependent on stent length and stent location within the vessel.