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Technical Brief

Effect of formalin fixation on thermal conductivity of the biological tissue

[+] Author and Article Information
Nachiket M. kharalkar

Electrical & Computer Engineering 1 University Station C0803 Austin, TX 78712kharalkar@gmail.com

Steven C. Bauserman

Department of Pathology, Brackenridge hospital Austin, TX 78701SBauserman@seton.org

Jonathan W. Valvano

Electrical & Computer Engineering 1 University Station C0803 Austin, TX 78712valvano@mail.utexas.edu

Corresponding author.

ASME doi:10.1115/1.4026559 History: Received March 20, 2008; Revised April 13, 2009

Abstract

Effect of formalin fixation on thermal conductivity of the biological tissues is presented. A self-heated thermistor probe was used to measure the tissue thermal conductivity. The thermal conductivity of muscle and fatty tissue samples was measured before the formalin fixation and then 27 hours after formalin fixation. The results indicate that the formalin fixation does not cause a significant change in the tissue thermal conductivity of muscle and fatty tissues. In the clinical setting, tissues removed surgically are often fixed in formalin for subsequent pathological analysis. These results suggest that, in terms of thermal properties, it is equally appropriate to perform in vitro studies in either fresh tissue or formalin-fixed tissue.

Copyright © 2013 by ASME
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