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Technical Briefs

Abdominal Aortic Aneurysm: From Clinical Imaging to Realistic Replicas

[+] Author and Article Information
Sergio Ruiz de Galarreta, Raúl Antón

Mechanical Department,
Tecnun,
Universidad de Navarra,
San Sebastián 20018, Spain

Aitor Cazón

CEIT and Mechanical Department,
Tecnun,
Universidad de Navarra,
San Sebastián 20018, Spain
e-mail: acazon@tecnun.es

Ender A. Finol

Department of Biomedical Engineering,
The University of Texas at San Antonio,
San Antonio, TX 78249

1Corresponding author.

Contributed by the Bioengineering Division of ASME for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received July 12, 2013; final manuscript received October 29, 2013; accepted manuscript posted October 31, 2013; published online December 4, 2013. Assoc. Editor: Jonathan Vande Geest.

J Biomech Eng 136(1), 014502 (Dec 04, 2013) (5 pages) Paper No: BIO-13-1314; doi: 10.1115/1.4025883 History: Received July 12, 2013; Revised October 29, 2013; Accepted October 31, 2013

The goal of this work is to develop a framework for manufacturing nonuniform wall thickness replicas of abdominal aortic aneurysms (AAAs). The methodology was based on the use of computed tomography (CT) images for virtual modeling, additive manufacturing for the initial physical replica, and a vacuum casting process and range of polyurethane resins for the final rubberlike phantom. The average wall thickness of the resulting AAA phantom was compared with the average thickness of the corresponding patient-specific virtual model, obtaining an average dimensional mismatch of 180 μm (11.14%). The material characterization of the artery was determined from uniaxial tensile tests as various combinations of polyurethane resins were chosen due to their similarity with ex vivo AAA mechanical behavior in the physiological stress configuration. The proposed methodology yields AAA phantoms with nonuniform wall thickness using a fast and low-cost process. These replicas may be used in benchtop experiments to validate deformations obtained with numerical simulations using finite element analysis, or to validate optical methods developed to image ex vivo arterial deformations during pressure-inflation testing.

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References

Upchurch, G. R., and Schaub, T. A., 2006, “Abdominal Aortic Aneurysm,” Am. Fam. Phys., 73(7), pp. 1198–1204. Available at http://www.aafp.org/afp/2006/0401/p1198.html
The United Kingdom Small Aneurysm Trial Participants, 2002, “Long-Term Outcomes of Immediate Repair Compared With Surveillance of Small Abdominal Aortic Aneurysm,” N. Engl. J. Med., 346(19), pp. 1445–1452. [CrossRef] [PubMed]
Fillinger, M. F., Marra, S. P., Raghavan, M. L., and Kennedy, F. E., 2003, “Prediction of Rupture Risk in Abdominal Aortic Aneurysm During Observation: Wall Stress Versus Diameter,” J. Vasc. Surg., 37, pp. 724–732. [CrossRef] [PubMed]
Doyle, B. J., Callahan, A., and McGloughlin, T. M., 2007, “A Comparison of Modelling Techniques for Computing Wall Stress in Abdominal Aortic Aneurysm,” Biomed. Eng. Online, 6, p. 38. [CrossRef] [PubMed]
Doyle, B. J., Callahan, A., Walsh, M. T., Grace, P. A., and McGloughlin, T. M., 2009, “A Finite Element Analysis Rupture Index (FEARI) as an Additional Tool for Abdominal Aortic Aneurysm Rupture,” Vasc. Dis. Prev., 6, p. 114–121. [CrossRef]
Van de Geest, J. P., Di Martino, E. E., Bohra, A., Makaroum, M.S., and Vorp, D. A., 2006, “A Biomechanics-Based Rupture Potential Index for Abdominal Aortic Aneurysm Risk Assessment,”. Ann. N.Y. Acad. Sci., 1085, p. 11–21. [CrossRef]
Doyle, B. J., Morris, L. G., Callahan, A., Kelly, P., Vorp, D. A., and Mc Gloughli, T.M., 2008, “3D Reconstruction and Manufacture of Real Abdominal Aortic Aneurysms: From CT Scan to Silicone Model,” ASME J. Biomech. Eng., 130(3), p. 034501. [CrossRef]
O'Brien, T., Morris, L. G., O'Donnell, M., Walsh, M. T., and Mc Gloughlin, T. M., 2005, “Injection-Moulded Models of Major and Minor Arteries: The Variability of Model Wall Thickness Owing to Casting Technique,” Proc. Inst. Mech. Eng., Part H: J. Eng. Med., 219, pp. 381–386. [CrossRef]
Raghavan, M. L., Kratzberg, E. M., Castro de Tolosa, E. M., Hanaoka, M. M., Walker, P., and Da Silva, E. S., 2006, “Regional Distribution of Wall Thickness and Failure Properties of Human Abdominal Aortic Aneurysm,” J. Biomech., 39(16), pp. 3010–3016. [CrossRef] [PubMed]
Doyle, B. J., Corbett, T. J., Cloonan, A. J., O'Donnell, M., Walsh, M. T., Vorp, D. A., and Mc Gloughli, T. M., 2009, “Experimental Modelling of Aortic Aneurysms: Novel Applications of Silicone Rubbers,” Med. Eng. Phys., 31, pp. 1002–1012. [CrossRef] [PubMed]
Raghavan, M. L., Webster, M. W., and Vorp, D. A., 1996, “Ex Vivo Biomechanical Behaviour of Abdominal Aortic Aneurysm: Assessment Using a New Mathematical Model,” Ann. Biomed. Eng., 24(5), pp. 573–582. [CrossRef] [PubMed]
Shum, J., DiMartino, E. S., Goldhamme, A., Goldman, D. H., Acker, L. C., Patel, G., Ng, J. H., Martufi, G., and Finol, E. A., 2010, “Semiautomatic Vessel Wall Detection and Quantification of Wall Thickness in Computed Tomography Images of Human Abdominal Aortic Aneurysms,” Med. Phys., 37(2), pp. 638–648. [CrossRef] [PubMed]
Martufi, G., Di Martino, E. S., Amon, C. H., Muluk, S. C., and Finol, E. A., 2009, “Three-Dimensional Geometrical Characterization of Abdominal Aortic Aneurysms: Image-Based Wall Thickness Distribution,” ASME J. Biomech. Eng., 131(6), p. 061015. [CrossRef]
Shum, J., Xu, A., Chatnuntawech, I., and Finol, E. A., 2011, “A Framework for the Automatic Generation of Surface Topologies for Abdominal Aortic Aneurysm Models,” Ann. Biomech. Eng.39(1), pp. 249–259. [CrossRef]
Shum, J., Martufi, G., Di Martino, E., Washington, C. B., Grisafi, J., Muluk, S. C., and Finol, E. A., 2011, “Quantitative Assessment of Abdominal Aortic Aneurysm Geometry,” Ann. Biomed. Eng., 39(1), pp. 277–286. [CrossRef] [PubMed]
Lee, K., Zhu, J., Shum, J., Zhang, Y., Muluk, S. C., Chandra, A., Eskandari, M. K., and Finol, E. A., 2013, “Surface Curvature as a Classifier of Abdominal Aortic Aneurysms: A Comparative Analysis,” Ann. Biomed. Eng., 31(3), pp. 562–576. [CrossRef]
Raut, S., Jana, A., De Oliveira, V., Muluk, S. C., and Finol, E. A., 2013, “The Importance of Patient-Specific Regionally Varying Wall Thickness in Abdominal Aortic Aneurysm Biomechanics,” ASME J. Biomech. Eng., 135(8), p. 081010. [CrossRef]
Mullins, L., 1969, “Softening of Rubber by Deformation,” Rubber Chem. Technol., 42, pp. 339–362. [CrossRef]
Lu, J., Zhou, X., and Raghavan, M. L., 2007, “Inverse Elastostatic Stress Analysis in PreDeformed Biological Structures: Demonstration Using Abdominal Aortic Aneurysms,” J. Biomech., 40, pp. 693–696. [CrossRef] [PubMed]
Gee, M. W., Reeps, C., Eckstein, H. H., and Wall, W. A., 2009, “Prestressing in Finite Deformation Abdominal Aortic Aneurysm Simulation,” J. Biomech., 42, pp. 1732–1739. [CrossRef] [PubMed]
Speelman, L., Bosboom, E. M. H., Shurink, G. W. H., Buth, J., Breeuwer, M., Jacobs, M. J., and Van de Vosse, F. N., 2009, “Initial Stress and Nonlinear Material Behavior in Patient-Specific AAA Wall Stress Analysis,” J. Biomech., 42, pp. 1713–1719. [CrossRef] [PubMed]
Riveros, F., Chandra, S. C., Finol, E. A., Gasser, T. C., and Rodriguez, J. F., 2013, “A Pull-Back Algorithm to Determine the Unloaded Vascular Geometry in Anisotropic Hyperelastic AAA Passive Mechanics,” Ann. Biomed.Eng., 41, pp. 694–708. [CrossRef] [PubMed]

Figures

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Fig. 1

Flow chart describing the artery replication process

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Fig. 2

Partition lines for the artery, with their proper connector pins (left), AM artery within the mold and filling the frame with silicon (center), and the final outer mold once cut open (right)

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Fig. 3

Process for the inner mold: silicone mold with the AM artery (left), filling the mold with liquid wax (center), and opening the AM artery to remove the wax mold (right)

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Fig. 4

Vacuum casting process for the artery: silicon mold with the wax mold inside ready for casting the PUR resin (left), opening the mold to remove the artery (center), and the final artery replica (right)

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Fig. 5

Stress-strain curves for PUR resins and 3D printing versus ex vivo experiments for normal and AAA arteries from Raghavan and Vorp [11]

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