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Research Papers

Determination and Modeling of the Inelasticity Over the Length of the Porcine Carotid Artery

[+] Author and Article Information
Alberto García

Research Assistant
e-mail: albegarc@unizar.es

Miguel A. Martínez

Professor
e-mail: miguelam@unizar.es

Estefanía Peña

Associated Professor
e-mail: fany@unizar.es
Aragón Institute of Engineering Research (I3A),
University of Zaragoza,
Zaragoza, 50018 Spain;
CIBER de Bioingeniería,
Biomateriales y Nanomedicina (CIBER-BBN),
Zaragoza, 50018 Spain

1Corresponding author.

Contributed by the Bioengineering Division of ASME for publication in the Journal of Biomechanical Engineering. Manuscript received July 25, 2012; final manuscript received December 6, 2012; accepted manuscript posted January 10, 2013; published online February 11, 2013. Assoc. Editor: Hai-Chao Han.

J Biomech Eng 135(3), 031004 (Feb 11, 2013) (9 pages) Paper No: BIO-12-1317; doi: 10.1115/1.4023371 History: Received July 25, 2012; Revised December 06, 2012; Accepted January 10, 2013

The study of the mechanical properties of swine carotids has clinical relevance because it is important for the appropriate design of intravascular devices in the animal trial phases. The inelastic properties of porcine carotid tissue were investigated. Experimental uniaxial cyclic tests were performed along the longitudinal and circumferential directions of vessels. The work focused on the determination, comparison, and constitutive modeling of the softening properties and residual stretch set of the swine carotid artery over long stretches and stress levels in both proximal and distal regions. It was observed that the residual strain depends on the maximum stretch in the previous load cycle. The strain was higher for distal than for proximal samples and for circumferential than for longitudinal samples. In addition, a pseudoelastic model was used to reproduce the residual stretch and softening behavior of the carotid artery. The model presented a good approximation of the experimental data. The results demonstrate that the final results in animal trial studies could be affected by the location studied along the length of the porcine carotid.

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Figures

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Fig. 1

Custom designed material testing machine (the top of the chamber used to enclose the tissue sample is not shown) and images of the tissue sample at increasing levels of axial deformation and after rupture and the loading protocol

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Fig. 2

Anti-smooth muscle actin histological study of media layer of the distal and proximal parts of the porcine carotid tissue; * in black: luminal site

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Fig. 3

Representative uniaxial stress-stretch of swine carotid obtained on the same specimen. Proximal and distal positions.

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Fig. 4

Residual stretch (λres) versus maximum stretch of the previous load cycle (λmax) for the different orientation and locations of the samples

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Fig. 5

Softening angle (angle between loading and unloading curves in degrees) for each level of stress analyzed (*p < 0.05,**p < 0.01)

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Fig. 6

Simulation results of uniaxial tension tests obtained with the constitutive law proposed for a representative uniaxial stress-stretch. Proximal and distal positions.

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