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TECHNICAL PAPERS

Intimal Hyperplasia and Wall Shear in Arterial Bypass Graft Distal Anastomoses: An In Vivo Model Study

[+] Author and Article Information
Robert S. Keynton

Department of Mechanical Engineering, University of Louisville, Louisville, KY 40292

Mary M. Evancho, Rick L. Sims

Division of Surgical Research, Summa Health System, Akron, OH 44309

Nancy V. Rodway

Department of Pathology, VA Medical Center, Canton, OH 44322

Andrea Gobin

Department of Biomedical Engineering, Rice University, Houston, TX 77251-1892

Stanley E. Rittgers

Division of Surgical Research, Summa Health System, Akron, OH 44309; Department of Biomedical Engineering, The University of Akron, Akron, OH 44235-0302

J Biomech Eng 123(5), 464-473 (May 16, 2001) (10 pages) doi:10.1115/1.1389461 History: Received June 02, 2000; Revised May 16, 2001
Copyright © 2001 by ASME
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References

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Figures

Grahic Jump Location
Nonlinear regression of: (top) IH versus Mean WSR (r=−0.483) and (bottom) IH versus OSI (r=0.600)
Grahic Jump Location
Linear regression of group averaged IH versus 1/(Absolute Peak WSR) (r=0.95)
Grahic Jump Location
Schematic of the distal anastomotic locations where velocity and histologic measurements were recorded for DR=1.0 (top) and 1.5 (bottom)
Grahic Jump Location
Mean WSR (solid line) and sWSSG (dashed line) distributions for the toe region and the artery floor for DR=1.0
Grahic Jump Location
Mean WSR (solid line) and sWSSG (dashed line) distributions for the toe region and the artery floor for DR=1.5
Grahic Jump Location
Longitudinal histological section (7.5×) of a typical distal anastomosis for DR=1.0 showing the development of intimal hyperplasia along: (top) the graft toe and (bottom) the graft heel (upper left) and artery floor (bottom). [White star denotes native artery, black star denotes e-PTFE graft and arrows identify regions of neointimal hyperplasia. Flow is from left to right.]
Grahic Jump Location
Longitudinal histological section (7.5×) of a typical distal anastomosis for DR=1.5 showing the development of intimal hyperplasia along: (top) the graft toe and (bottom) the graft heel (upper left) and artery floor (bottom). [White star denotes native artery, black star denotes e-PTFE graft and arrows identify regions of neointimal hyperplasia. Flow is from left to right.]
Grahic Jump Location
Distribution of IH (mean±S.D.) along the toe region (0 mm to 16 mm from the anastomotic toe) for the cases: (top) DR=1.0 and (bottom) DR=1.5. [number of samples=6 unless otherwise noted above error bars]
Grahic Jump Location
Distribution of IH (mean±S.D.) along the artery floor (−20 mm to 15 mm from the anastomotic toe) for the cases: (top) DR=1.0 and (bottom) DR=1.5. [number of samples=6 unless otherwise noted above error bars]
Grahic Jump Location
Linear regression of: (top) IH versus Mean WSR (r=−0.406) and (bottom) IH versus Absolute Mean WSR (r=−0.370)
Grahic Jump Location
Cumulative percent IH versus (top) Mean WSR and (bottom) Absolute Mean WSR [vertical line denotes the mean WSR in the native artery prior to grafting]

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