Studies on the Three-Dimensional Temperature Transients in the Canine Prostate During Transurethral Microwave Thermal Therapy

[+] Author and Article Information
Jing Liu

School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907-1288

Liang Zhu

Department of Mechanical Engineering, University of Maryland at Baltimore County, Baltimore, MD 21250

Lisa X. Xu

School of Mechanical Engineering, Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907-1288e-mail: lxu@ecn.purdue.edu

J Biomech Eng 122(4), 372-379 (Mar 22, 2000) (8 pages) doi:10.1115/1.1288208 History: Received February 22, 1999; Revised March 22, 2000
Copyright © 2000 by ASME
Your Session has timed out. Please sign back in to continue.


Astrahan,  V. W., Sapozink,  M. D., Cohen,  D., Luxton,  G., Kampp,  T. D., Boyd,  S., and Petrovich,  Z., 1989, “Microwave Applicator Transurethral Hyperthermia of Benign Prostatic Hyperplasia,” Int. J. Hyperthermia, 5, pp. 283–296.
Baert,  L., Ameye,  F., Willemen,  P., Vandenhove,  J., Lauweryns,  J., Astrahan,  M. A., and Petrovich,  Z., 1990, “Transurethral Microwave Hyperthermia for Benign Prostatic Hyperplasia: Preliminary Clinical and Pathological Results,” J. Urol. (Baltimore), 144, pp. 1383–1387.
Bdesha,  A. S., Bunce,  C. J., Kelleher,  J. P., Shell,  M. E., Vukusic,  J., and Witherow,  R. O’N, 1993, “Transurethral Microwave Treatment for Benign Prostatic Hypertrophy: a Randomized Controlled Clinical Trial,” Br. Med. J., 306, pp. 1293–1296.
Homma,  Y., and Aso,  Y., 1993, “Transurethral Microwave Thermotherapy for Benign Prostatic Hyperplasia: a 2-Year Follow-Up Study,” J. Endourology, 7, pp. 261–265.
Larson,  T. R., Bostwick,  D. G., and Corica,  A., 1996, “Temperature-Correlated Histopathologic Changes Following Microwave Thermoablation of Obstructive Tissue in Patients With Benign Prostatic Hyperplasia,” Urol., 47, pp. 463–469.
Marteinsson,  V. T., and Due,  J., 1994, “Transurethral Microwave Thermotherapy for Uncomplicated Benign Prostatic Hyperplasia,” Scand. J. Urol. Nephrol., 28, pp. 83–82.
de la Rosette,  J. J. M. C. H., Froeling,  F. M. J. A., and Debruyne,  F. M. J., 1993, “Clinical Results With Microwave Thermotherapy of Benign Prostatic Hyperplasia,” Eur. Urol., 23, (suppl. 1), pp. 68–71.
Sapozink,  M. D., Boyd,  S. D., Astrahan,  M. A., Jozaef,  G., and Petrovich,  Z., 1990, “Transurethral Hyperthermia for Benign Prostatic Hyperplasia: Preliminary Clinical Results,” J. Urol. (Baltimore), 143, pp. 944–950.
Martin,  G. T., Haddad,  M. G., Cravalho,  E. G., and Bowman,  H. F., 1992, “Thermal Model for the Local Microwave Hyperthermia Treatment of Benign Prostatic Hyperplasia,” IEEE Trans. Biomed. Eng., 39, pp. 836–844.
Xu, L. X., Rudie, E., and Holmes, K. R., 1993, “Transurethral Thermal Therapy (T3) for the Treatment of Benign Prostatic Hyperthermia (BPH) in the Canine: Analysis Using Pennes’ Bioheat Transfer,” in: Advances in Heat and Mass Transfer in Biotechnology, ASME HTD-Vol. 268, pp. 31–35.
Yuan, D. Y., Valvano, J. W., Rudie, E. N., and Xu, L. X., 1995, “2-D Finite Difference Modeling of Microwave Heating in the Prostate,” in: Advances in Heat and Mass Transfer in Biotechnology, ASME HTD-Vol. 322/BED-Vol. 32, pp. 107–113.
Zhu,  L., Xu,  L. X., and Chencinski,  N., 1998, “Quantification of the 3-D Electromagnetic Power Absorption Rate in Tissue During Transurethral Prostatic Microwave Thermotherapy Using Heat Transfer Model,” IEEE Trans. Biomed. Eng., 45, pp. 1163–1172.
Patel,  U. H., and Babbs,  C. F., 1993, “Development of a Rapidly Computable Descriptor of Prostate Tissue Temperature During Transurethral Conductive Heat Therapy for the Benign Prostate Hyperplasia,” Med. Biol. Eng. Comput., 31, pp. 475–481.
Loyd,  D., Karlsson,  M., Erlandsson,  B. E., Sjodin,  J. G., and Ask,  P., 1997, “Computer Analysis of Hyperthermia Treatment of the Prostate,” Adv. Eng. Softw., 28, pp. 347–351.
Sturesson,  C., and Engels,  S. A., 1996, “Theoretical Analysis of Transurethral Laser-Induced Thermotherapy for Treatment of Benign Prostatic Hyperplasia: Evaluation of a Water-Cooled Applicator,” Phys. Med. Biol., 41, pp. 445–463.
Bigler,  S. A., Deering,  R. E., and Brawer,  M. K., 1993, “Comparison of Microscopic Vascularity in Benign and Malignant Prostate Tissue,” Hum. Pathol., 24, pp. 220–226.
Nissenkorn,  I., and Meshorer,  A., 1993, “Temperature Measurements and Histology of the Canine Prostate During Transurethral Hyperthermia,” J. Urol. (Baltimore), 149, pp. 1613–1616.
Xu, L. X., 1999, “New Development in Bioheat and Mass Transfer Modeling,” in: Annual Review of Heat Transfer, Chang-Lin Tien, ed., X, Chap. 1, Begell House, New York.
Ozisik, M. N., 1993, Heat Conduction, 2nd ed., Wiley New York.
Xu,  L. X., Zhu,  L., and Holmes,  K. R., 1998, “Thermoregulation in the Canine Prostate During Transurethral Microwave Hyperthermia, Part I: Temperature Response,” Int. J. Hyperthermia, 14, pp. 29–37.
Arkin,  H., Holmes,  K. R., and Chen,  M. M., 1986, “A Sensitivity Analysis of the Thermal Pulse Decay Method for Measurement of Local Tissue Conductivity and Blood Perfusion,” ASME J. Biomech. Eng., 108, pp. 54–58.
Chato, J. C., 1991, “Fundamentals of Bioheat Transfer,” in: Thermal Dosimetry and Treatment Planning, Gautherie, M., ed., Springer-Verlag, New York, Chap. 1.
Xu, L. X., Zhu, L., and Holmes, K. R., 1998, “Blood Perfusion Measurements in the Canine Prostate During Transurethral Hyperthermia,” in: Annals of New York Academia of Sciences, Diller, K. R., ed., 858, Chap. 2, pp. 21–29.
Zhu, L., Xu, L. X., Yuan, D. Y., and Rudie, E. N., 1996, “Electromagnetic (EM) Quantification of the Microwave Antenna for the Transurethral Prostatic Thermotherapy,” in: Advances in Heat and Mass Transfer in Biotechnology, ASME HTD-Vol. 337/BED-Vol. 34, pp. 17–20.
Henriques,  F. C., and Moritz,  A. R., 1947, “Studies of Thermal Injury, I. The Conduction of Heat to and Through Skin and the Temperatures Attained Therein: A Theoretical and an Experimental Investigation,” Am. J. Pathol., 23, pp. 531–549.
Pearce, J., Liao, W. H., and Thomsen, S., 1998, “The Kinetics of Thermal Damage: Estimation and Evaluation of Model Coefficients,” in: Advances in Heat and Mass Transfer in Biotechnology, ASME HTD-Vol. 362/BED-Vol. 40, pp. 71–75.
Bhowmick, S., and Bischof, J. C., 1998, “Supraphysiological Thermal Injury in Dunning AT-1 Prostate Tumor Cells,” in: Advances in Heat and Mass Transfer in Biotechnology, ASME HTD-Vol. 362/BED-Vol. 40, pp. 77–78.
Moritz,  A. R., and Henriques,  F. C., 1947, “Studies of Thermal Injury II: the Relative Importance of Time and Surface Temperature in the Causation of Cutaneous Burns,” Am. J. Pathol., 23, pp. 695–720.
Diller, K. R., and Klutke, G. A., 1993, “Accuracy of the Henriques Model for Predicting Thermal Burn Injury,” in: Advances in Bioheat and Mass Transfer, ASME HTD-Vol. 268, pp. 117–123.
Torvi,  D. A., and Dale,  J. D., 1994, “A Finite Element Model of Skin Subjected to a Flash Fire,” ASME J. Biomech. Eng., 116, pp. 250–255.
Xu,  Y., and Qian,  R., 1995, “Analysis of Thermal Injury Process Based on Enzyme Deactivation Mechanisms,” ASME J. Biomech. Eng., 117, pp. 462–465.
Weinbaum,  S., Jiji,  L. M., and Lemons,  D. E., 1984, “Theory and Experiment for the Effect of Vascular Microstructure on Surface Tissue Heat Transfer—Part I: Anatomical Foundation and Model Conceptualization,” ASME J. Biomech. Eng., 106, pp. 321–330.


Grahic Jump Location
Canine prostate and its capsular vascular network: (a) half cross-sectional slice; (b) longitudinal section (enlarged)
Grahic Jump Location
Canine prostatic vasculature
Grahic Jump Location
Schematic cross section of the canine prostatic tissue and vessels: (a) prostate and catheter; (b) catheter (enlarged)
Grahic Jump Location
Three-dimensional configuration of the prostate under microwave heating
Grahic Jump Location
Temperature and blood perfusion measurement in the canine prostate
Grahic Jump Location
Comparison of the theoretical and experimental temperature responses at various probe locations (r,θ,z:#1:0.01 m, 126.9 deg, 0.015 m; #2: 0.009 m, 160 deg, 0.013 m; #3: 0.0125 m, 135.0 deg, 0.011 m)
Grahic Jump Location
Steady-state temperature distribution in the midplane (z=0.015 m) during 5 W heating
Grahic Jump Location
Steady-state temperature distribution at θ=0 deg during 5 W heating
Grahic Jump Location
Temperature profile at r=0.008 m,θ=0,z=0.015 m with respect to the perfusion rate
Grahic Jump Location
Perfusion-dependent radial steady-state temperature distribution at (θ=0,z=0.015 m) under 5 W heating
Grahic Jump Location
Transient temperature elevation at r=0.008 m,θ=0,z=0.015 m under continuous heating
Grahic Jump Location
Influence of the chilled water temperature on the urethral wall temperature (r=0.003 m,θ=0,z=0.015 m)
Grahic Jump Location
Steady-state temperature distributions at (θ=0,z=0.015 m) under 5 W heating with different convection coefficients



Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In